中文摘要：

试验通过体外抑菌、电镜观察以及对兔乳房炎的临床治疗三个方面对比小檗碱与青、链霉素对金黄色葡萄球菌的抑制效果。结果表明,小檗碱对金黄色葡萄球菌抑制效果优于青、链霉素,且能使金黄色葡萄球菌表面变粗糙凸起,从而发挥抑菌作用,对金黄色葡萄球菌诱导的兔乳房炎的白细胞、炎性因子TNF-α、IL-6有明显的抑制作用且起效慢于青、链霉素,但稳定性优于青、链霉素。

英文摘要：

The purpose of this study was to compare the effect of berberine with penicillin and streptomycin on the growth of staphylococcus aureus using bacteriostasis experiment in vitro,electron microscopy observation and the clinical treatment to rabbit mastitis. The results showed that berberine played a role in bacteriostasis by making the staphylococcus aureus＇ surface rough.Moreover,berberine＇s bacteriostatic trend is superior to penicillin and streptomycin. Berberine can enhance the production of the white blood cells,inflammatory factor TNF-αand IL-6,and has obvious inhibitory effects on rabbit mastitis caused by staphylococcus aureus,and its stability is better than penicillin and streptomycin.