中文摘要：

JNK介导细胞凋亡的作用与多种疾病的发生有关,因此有关JNK促细胞凋亡分子机制的研究不断深入。本文综述了与JNK介导细胞凋亡相关的多种疾病并概括了JNK促细胞凋亡的主要的上游激活物和下游分子信号途径,同时根据近年来研究热点,强调了Hsp72作为JNK天然抑制剂对于抑制JNK信号通路激活的重要性。JNK又称为应激活化蛋白激酶,在应激条件下JNK激活,进而引发细胞凋亡等生理变化,从而对机体产生不利影响。而在畜牧养殖生产中,环境等的应激因素往往是不可避免的,因而减少应激以及应激时细胞内JNK的激活将有利于经济动物的健康生长,明确JNK的促凋亡机制并寻求且充分利用其有效的天然抑制剂对于疾病治疗以及畜牧经济发展具有重要意义。

英文摘要：

Many diseases are associated with the cell apoptosis mediated by （c-Jun N-terminal kinase （JNK）, so that the research about the molecular mechanism of JNK mediated cell apoptosis is gradually going deep. This paper re- viewed the diseases closely related to the cell apoptosis mediated by JNK, summarized the main upstream activators and downstream apoptotic signaling pathways and underlined the importance of Hsp72 for suppressing the activation of JNK signaling pathways according to the papers published recent years. JNK is also called stress activated protein ki- nase, which adversely affects the organisms by inducing cell apoptosis and other physiological changes under stress conditions. However, the stress factors such as environment stress are often inevitable in animal breeding and produc- tion. Therefore, to reduce stress and JNK＇s activation under stress will be helpful to healthily growth of economic ani- mals and also to reveal the machanisim of JNK promoting cell apoptosis and make a good use of the effective natural inhibitor will be of great value for the treatment of diseases and economy of animal husbandry.