中文摘要：

在用磁控溅射合成具有一定特性的TiO2薄膜的基础上，研究了一种表面生物化学方法对其生物学性质的改善。先利用NaOH溶液活化TiO2薄膜表面，，使其产生羟基基团，再通过氨丙基三乙氧基硅烷（APTE）偶联固定Ⅰ型胶原。采用傅立叶红外光谱（FTIR）、X射线光电子能谱（XPS）和原子力显微镜（AFM）对每步处理后的材料表面进行分析和测试。通过血小板粘附试验评价薄膜材料的血栓形成能力。研究结果显示：通过表面活化后涂覆APTE并固定Ⅰ型胶原修饰后的TiO2薄膜表面，其血栓形成能力得到明显提高。

英文摘要：

The surface modification has become a focus in biomaterials research area. In this work, on the basis of our previous study, the TiO2 films were synthesized using unbalance magnetron sputtering （UBMS） to improve its thrombus formation ability at a certain extent. The chosed TiO2 film was pretreated by NaOH solution for activity. Using bio-chemical modification method, type Ⅰ collagen was further immobilized on the TiO2 film surface by silane coupling reagent of aminopropyltriethoxysilane （APTE）. X-ray photoelectron spectroscopy （XPS）, fourier transform infrared spectroscopy （FTIR） and atomic force microscope （AFM） were used to investigate the characteristics of the bio-chemical modificated TiO2 film and the controlled TiO2 film. At the same time, the contact angle of the films were measured. The thrombus formation ability of the films was studied by in vitro platelets adhesion test. The results showed that the bio-chemical modification can meet the biocompatibility requirement of TiO2 film for biomedical microcoil application to hemangioma treatment.