中文摘要：

目的研究热休克蛋白70（HSP70）在慢性阻塞性肺疾病（COPD）中的表达情况与临床意义。方法通过免疫组化和PCR技术，研究COPD患者肺组织标本中HSP70的表达，以及与肺功能的关系。所有患者分为三组，正常组34例，轻度COPD组33例，中重度COPD组15例。结果82例患者肺组织中，阳性率100%，随着严重程度的不同，表达有逐渐增强的趋势，且在吸烟组的非CODP患者的表达高于非吸烟组。结论HSP70在COPD呈高表达状况，且与肺功能的严重程度和吸烟密切相关，对肺组织的慢性损伤有保护作用。

英文摘要：

Objective To study the expression of heat shock protein 70 （HSP70） in chronic obstructive pulmonary disease （COPD） tissues and its clinical significance. Methods Immunohistochemical methods and PCR techniques were used to evaluate the expression of HSP70 in lung tissue of COPD patients. Statistic approach was used to analyse the relationship between HSP70 and lung function. All the patients were divided into three groups, 34 patients in the normal group, 33 in the mild COPD group, and 15 in the moderate or severe COPD group. Results The expression of HSP70 was positive in all cases and its expression had a tendency to increase according to the severity of COPD. Among the patients who were in the same group, the expression of HSP70 was higher in smokers than nonsmokers. Conclusion The expression of HSP70 is high in all COPD patients and it might relate to the severity of COPD and cigarette smoking. HSP70 might have a protective effect on chronic lung injury.