中文摘要：

朊病毒病（Prion diseases）是一种由细胞型朊蛋白（PrPC）构象发生改变所形成的致病型朊蛋白（PrPSc）大量沉积在细胞中而引起的一种致命性神经退行性疾病,致死率高达100%。目前为止,该病还没有一种确切的治疗方法,严重威胁人类和动物的健康。随着对朊病毒病研究深入,科学家们发现细胞自噬,RNA干扰,PrP抗体、核酸疫苗、一些药物及化合物在疾病治疗方面有积极作用。我们将近些年来在治疗朊病毒病方面具有潜在应用价值的方法和理论做具体阐述。

英文摘要：

Prion diseases are neurodegenerative and infectious disorders characterized by the aggregation of a misfolded isoform（PrPSc）of the cellular prion protein（PrPC）.Because of its high lethality and incidence,currently,there is not a effective way to cure these diseases,which have already became one of a serious problem that threaten human and animal health.As development of technology and deeper research in neurodegenerative diseases,scientist found that autophagy,RNA interference,anti-PrP-antibody,nucleic acid vaccines and some medicine and compounds have prominent effect on the treatment of diseases.In this review,we demonstrate some methods and theories which have potential value in treating prion diseases.