中文摘要：

摘要：利用Pmp0/0型青年鼠和老年鼠，通过水迷宫试验、跳台试验和自主活动试验，探讨Ppm0/0型小鼠从青年到老年是否遵循学习和记忆能力下降的一般生理规律，从而反映PrPc蛋白是否对神经系统的老化过程有影响。结果表明：在Morris水迷宫定位航行试验中，2组鼠的潜伏期在统计学上差异不显著，但是青年鼠的潜伏期均低于老年鼠；在空间探索试验中，Prnp0/0型青年鼠穿越平台次数比老年鼠多，差异显著（P〈0．05），青年鼠第1次穿越平台的时间比老年鼠短。在跳台试验中，Pm妒型青年鼠和老年鼠第1天的错误次数差异显著（P〈0．05），24h后错误次数差异极显著（P〈0．01），第1次跳下平台的时间即潜伏期差异极显著（P〈0．01）。在自主活动试验中，青年鼠较老年鼠活动强，在第4天差异极显著（P〈0．01），且随着时间的延长，2组鼠的活动次数都减少。Pmp0／0青年鼠的学习记忆能力强于老年鼠，反映出PrPc蛋白的缺失并没有显著影响到小鼠神经系统的老化过程。

英文摘要：

The purpose of this study was to explore whether the learning and memory ability of Prnp~/~ mice follow the general physical laws of declining from youth to old age and to reflect whether PrP~ protein affect the aging process of the nerve system by water maze test, jumping experimental and independent activities. The results showed that the latency period of the two groups of mice was not statistically signifi- cant, but the latency period of the young mice was lower than that of the aged mice in the Morris water maze navigation test; In space exploration test, the number of the two groups of mice crossing the plat- form was significantly different （ P 〈 0.05）, and the number of the Prnp~/~ young mice was larger than that of the aged mice. In addition, the time for the young mice to first cross the platform was shorter than that of the aged. In jumping trials, the number of errors was significantly different （ P 〈 0.05）, after 24 h, the difference of error number was extremely significant （ P 〈 0.01 ）, and the difference of the time for the first jumping off the platform was also extremely significant （P 〈 0.01）. In the experiment of in- dependent activities, the young mice were more active than the aged, on the fourth day, the difference was extremely significant （P 〈 0.01）, and with time going on, the number of activities of the two groups of mice decreased. Conclusion, learning and memory ability of young mice were better than those of the aged, reflecting that the lack of PrPc protein did not significantly affect the aging process of the nerve sys- tem in mice.