中文摘要：

目的研究腹腔注射左旋多巴（L-dopa）对豚鼠形觉剥夺性近视眼屈光状态及视网膜多巴胺含量的影响。方法眼罩遮盖建立豚鼠形觉剥夺性近视眼模型，分为正常对照组、L—dopa组（10mg／kg）、生理盐水组、遮盖组、遮盖＋L-dopa组、遮盖＋生理盐水组6个组。遮盖10d后，测定角膜曲率半径、眼球屈光度和眼轴长度，高效液相色谱检测视网膜多巴胺含量。结果眼罩遮盖10d后，豚鼠遮盖眼眼轴延长、近视形成，视网膜多巴胺含量降低（P〈0．05），但角膜曲率半径无明显变化。腹腔注射L-dopa引起遮盖眼视网膜多巴胺含量增加、近视程度减轻（P〈0．05），但对正常豚鼠眼球的屈光发育无明显影响（P〉0．05）。腹腔注射生理盐水后，豚鼠眼球屈光状态和视网膜多巴胺含量无明显变化（P〉0．05）。结论腹腔注射L—dopa能通过补充遮盖眼视网膜多巴胺含量，抑制豚鼠形觉剥夺性近视的形成。

英文摘要：

Objective Some studies on myopia animal model showed that dopamine plays a regulative role in the pathogenesis and development of myopia, and its level in retina is obviously reduced in form deprived myopia and len-induced myopia eye. The present study was to investigate the effect of intraperitoneal levodopa （L-dopa） on ocular refractive state and retinal dopamine content in form deprivation myopia eye of guinea pig. Methods Form deprivation myopia in the right eyes of 50 guinea pigs was induced by translucent goggles. The guinea pigs were divided into 6 groups according to the different interferring way（ 10 rabbits for each group）, including L-dopa group, saline group, deprivation group, deprivation plus L-dopa group,deprivation plus saline group,and 10 normal eyes worked as control. L-dopa （10 mg/kg） was injected into the abdominal cavity of guinea pig once per day. After 10 days of goggles occluding, the corneal radius of curvature, ocular refractive degree and axial length were measured by using keratometer,scotoscope and A-type sonogrape. The dopamine content in retina was detected by high performance liquid chromatography. Results After 10 days, the refractive statue showed the myopia and ocular axle was elongated in model eyes and the dopamine in retina was decreased in comparison with self-control eyes and normal control eyes （P 〈 0. 05 ） , but no significant change in corneal radius of curvature was found in model eyes. Repeated intraperitoneal injection of L-dopa could inhibit the myopic shift due to goggles occluding and compensate retinal dopamine （ P 〈 O. 05 ）. After injection of L-dopa, the dopamine content in retina was（ 1.74 ± 0.55）ng in the unoccluding eyes, showing an insignificant increase in comparison with control eyes（ 1.62 ± 0. 53 ） ng （P 〉 0. 05 ）. However,the dopamine level was significantly reduced in the model eyes comapried with normal eyes （ P 〉 0. 05 ）. The dopamine content in retina of form-deprived plus L-dopa injection group was signi