中文摘要：

在严重尖锐胰腺炎(树液) 的死亡的背景一主要原因是由于细菌的 translocation 的严重感染。一些临床的研究作为新策略建议了那 ecoimmunonutrition (EIN ) 治疗最好在树液上完成病人。但是 EIN 的效果的精确机制上的实验研究是报导的更少。在这研究，我们主要在 dogs.Methods 树液的树液模型在细菌的 translocation 上调查了 EIN 的效果被导致由后退进在健康的混合的狗的胰腺的管的 5% 钠 taurocholate 的注入。树液狗与非肠道的营养(PN ) 或元素的 enteral 营养(EEN ) 或 EIN 被支持。浆液淀粉酶，浆液 aminotransferase 和血浆内毒素的层次在胰腺炎正式就职前后被检测。在在营养支持以后的第 7 天，腹液体， mesenteric 淋巴节点(MLN ) ，肝，和胰与标准技术为细菌的文化被收集观察细菌的 translocation 的发生。胰的病理变化被胰的严厉的组织病理学说的分级并且得分分析，并且肠的 mucosal 损坏的度被与 PN 和 EEN 相比测量 ileum.Results 的 mucosal 厚度，绒毛高度，和地窟深度估计， EIN 显著地减少了浆液淀粉酶的层次，细菌的 translocation 的浆液 aminotransferase ，血浆内毒素，和发生。与其它相比，而且，组织学在胰和回肠损害(回肠 mocosa 厚度，绒毛高度，和地窟深度) 发炎得分被 EIN 显著地减轻(P < 0.05 ) 。而且有关肝功能，丙氨酸 aminotransferase， aspartate aminotransferase 和白朊的浆液层次在 EIN group.Conclusion 显著地正在改善，我们的结果建议 EIN 能维持肠的 mucosal 障碍的完整并且在树液狗减少细菌的 translocation 的发生。早 EIN 是为树液狗的安全、更有效的处理。

英文摘要：

Background One of the major causes of death in severe acute pancreatitis （SAP） is severe infection owing to bacterial translocation. Some clinical studies suggested that ecoimmunonutrition （EIN） as a new strategy had better treatment effect on SAP patients. But the experiment studies on the precise mechanism of the effect of EIN were less reported. In this study, we mainly investigated the effects of EIN on bacterial translocation in SAP model of dogs. Methods SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in healthy hybrid dogs. The SAP dogs were supported with either parenteral nutrition （PN） or elemental enteral nutrition （EEN） or EIN. The levels of serum amylase, serum aminotransferase and plasma endotoxin were detected before and after pancreatitis induction. On the 7th day after nutrition supports, peritoneal fluid, mesenteric lymph nodes （MLN）, liver, and pancreas were collected for bacterial culture with standard techniques to observe the incidence of bacterial translocation. Pathology changes of pancreas were analyzed by histopathologic grading and scoring of the severity of pancreas, and the degree of intestinal mucosal damage was assessed by measuring mucosal thickness, villus height, and crypt depth of ileum. Results Compared with PN and EEN, EIN significantly decreased the levels of serum amylase, serum aminotransferase, plasma endotoxin, and the incidence of bacterial translocation. Furthermore, compared with the others, the histology scores of inflammation in pancreas and the ileum injury （ileum mocosa thickness, villus height, and crypt depth） were significantly alleviated by EIN （P〈0.05）. Moreover, concerning liver function, the serum levels of alanine aminotransferase, aspartate aminotransferase and albumin were ameliorating significantly in the EIN group. Conclusion Our results suggested that EIN could maintain the integrity of intestinal mucosal barrier and reducing the incidence of bacterial translocation in SAP do