中文摘要：

为探讨兰州市大气污染对心脑血管疾病住院的急性健康效应,采用单向回顾性配对病例交叉设计,分析了兰州市2001~2005年大气污染物浓度（PM10、SO2及NO2）短期升高对人群心脑血管疾病住院的影响.结果表明,单向回顾性1：2匹配病例交叉研究的效应值（ORs）最大,在控制同期天气因素后,滞后3d PM10浓度每升高10μg/m3,总心脑血管疾病及心血管疾病住院的ORs分别为1.002（95%CI：1.001~1.003）和1.002（95%CI：1.001~1.003）;无滞后SO2浓度每升高10μg/m3对总心脑血管疾病住院的OR值为1.005（95%CI：1.000~1.009）;NO2在滞后1d浓度每升高10μg/m3对总心脑血管疾病OR值为1.022（95%CI：1.014~1.030）;对心血管疾病及脑血管疾病住院影响均在滞后2d达到最大,ORs值分别为1.021（95%CI：1.011~1.030）和1.019（95%CI：1.005~1.033）.在多污染物模型中,PM10仍对心血管疾病住院人数增加有统计学意义;NO2对心脑血管疾病住院的影响均较单污染物模型中大.

英文摘要：

To explore the acute effect of air pollution and hospital admissions for cardiovascular and cerebrovascular diseases in Lanzhou,unidirectional retrospective case-crossover design was used to analyze the relation of daily average concentration of air pollutants（PM10、SO2 and NO2） in short-time increased with the cardiovascular and cerebrovascular diseases hospitalizations from 2001 to 2005.The results showed that the unidirectional case-crossover design with 1：2 matched pairs had the highest odds ratios between air pollutants and hospital admissions.After being adjusted for meteorological factors,an increase of 10μg/m3 in PM10 was significantly associated with 1.002（95%CI： 1.001~1.003） and 1.002（95%CI： 1.001~1.003） at 3 days lag increase respectively for total circulatory diseases（ICD10：I00~I99） and cardiovascular disease（ICD10：I00~I52）;an increase of 10μg/m3 in SO2 was associated with 1.005（95%CI：1.000~1.009） for total circulatory diseases hospitalizations;a 10μg/m3 increment in NO2 was significantly associated with hospital admissions on value of ORs 1.022（95%CI：1.014~1.030） for the total circulatory diseases at 1day lag,1.021（95%CI： 1.011~1.030） for cardiovascular disease at 2 days lag,1.019（95%CI：1.005~1.033） for cerebrovascular diseases（ICD10： I60~I69） at 2 days lag respectively.In the multiple air pollutant models,an increase of 10μg/m3 in PM10 was also associated with cardiovascular and cerebrovascular diseases hospitalizations,the OR values of NO2 were higher than the single pollutant models.