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基于R语言的养阴通脑颗粒总黄酮提取优化
  • ISSN号:1673-1727
  • 期刊名称:中华中医药杂志
  • 时间:2015.7.1
  • 页码:2486-2489
  • 分类:R255.2[医药卫生—中医内科学;医药卫生—中医学]
  • 作者机构:浙江中医药大学心脑血管研究所,浙江杭州310053
  • 相关基金:国家自然科学基金项目(81374053,81274176); 浙江省卫生高层次创新人才培养工程项目
  • 相关项目:基于方剂配伍和药物体内相互作用理论的芪芎有效部位配伍抗脑缺血性损伤机制研究
中文摘要:

目的研究缺血性脑卒中急性期中医证型与危险因素的相关性,以期为中医药临床诊疗思路及中医临床辨证论治提供参考依据。方法将缺血性脑卒中患者304例依照中医辨证分型标准分为5型,研究缺血性脑卒中急性期中医证型与年龄、高血压、糖尿病、高脂血症等危险因素的相关性,采用χ2检验和logistic回归分析方法进行统计学研究。结果缺血性脑卒中急性期中医证型分为5个,以气虚血瘀证最多,其后依次为风痰瘀阻证、阴虚风动证、肝阳上亢证和痰热腑实证。本研究304例患者中,男性200例,占65.79%,男性患者中以风痰瘀阻证最多;女性104例,占34.21%,女性患者中以气虚血瘀证最多。肝阳上亢证与年龄、吸烟、糖尿病和高同型半胱氨酸血症(HHcy)关系密切(P〈0.05);风痰瘀阻证与HHcy关系密切(P〈0.05);阴虚风动证与年龄、高血压和糖尿病关系密切(P〈0.05)。结论急性缺血性脑卒中的危险因素与中医证型有一定的相关性,肝阳上亢证的危险因素是年龄、吸烟、糖尿病和HHcy;风痰瘀阻证的危险因素是HHcy;阴虚风动证的危险因素是年龄、高血压和糖尿病。

英文摘要:

Objective: To study the correlation between TCM syndrome types and risk factors in acute stage of ischemic stroke,so as to provide reference for the clinical diagnosis and the clinical differentiation and treatment of TCM. Methods: 304 cases with ischemic stroke,according to TCM syndrome differentiation standards,were divided into 5 types to research the correlation of the acute ischemic stroke syndromes with age,hypertension,diabetes,hyperlipidemia and other risk factors. 2 test and Logistic regression analysis method were used to study.Results: The TCM Syndromes of acute ischemic stroke were divided into 5 types,with Qi deficiency and blood stasis being the most,followed by wind and phlegm stasis syndrome,wind formation from Yin deficiency,syndrome of upper hyperactivity of liver yang and phlegm heat and constipation. Among 304 patients,200 were males,accounting for 65.8%,and the majority of the male patients had wind and phlegm stasis syndrome;104 were female,accounting for 34.2%,and the majority of female patients had Qi deficiency and blood stasis syndrome. Syndrome of upper hyperactivity of liver yang was closely related to age,smoking,diabetes and HHcy(P 0.05). Wind and phlegm stasis syndrome was closely related to HHcy(P 0.05). Wind formation from Yin deficiency was closely related to age,hypertension and diabetes(P 0.05). Conclusion: The risk factors of acute ischemic stroke are related to TCM syndromes. The risk factors of syndrome of upper hyperactivity of liver Yang are age,smoking,diabetes and HHcy;the risk factor of wind and phlegm stasis syndrome is HHcy;the risk factors of wind formation from Yin deficiency are age,hypertension and diabetes.

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期刊信息
  • 《中华中医药杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国中医药学会
  • 主编:佘倩
  • 地址:北京市和平街北口樱花路甲4号
  • 邮编:100029
  • 邮箱:
  • 电话:
  • 国际标准刊号:ISSN:1673-1727
  • 国内统一刊号:ISSN:11-5334/R
  • 邮发代号:18-90
  • 获奖情况:
  • 国家中医药管理局优秀期刊一等奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:36061