脑缺血疾病是现代人类健康和生命的主要杀手之一。近年研究发现,神经细胞凋亡是脑缺血疾病造成神经系统损伤的重要机制,神经细胞凋亡通路主要包括线粒体通路、死亡受体通路、PARP/AIF通路。基于神经细胞凋亡与脑缺血损伤关系的深入研究,抗凋亡治疗已经成为了治疗脑缺血疾病的重要途径。
Cerebral ischemia has been one of the killers in human health and lives.In recent years,it has been found that the apoptosis of neurons is an important mechanism leading to cerebral ischemia injury.Cerebral ischemia triggers three general pathways of apoptosis: mitochondrial mediated apoptosis,death receptor mediated apoptosis and PARP as a regulator of AIF mediated apoptosis.Because of the intensive study on the relationship between neurons apoptosis and cerebral ischemia,anti-apoptotic therapies have been valuable methods.