中文摘要：

考察不同剂量、不同给药途径的AGE混悬液对急性辐射损伤小鼠防护作用,研究该药物治疗急性辐射损伤小鼠的最佳治疗方案.小鼠经60 Coγ射线一次性全身照射;设照射剂量8.0 Gy组,照射后皮下或腹腔注射50 mg/（kg·d-1）、100 mg/（kg·d-1）、200 mg/（kg·d-）的AGE混悬液;均连续注射3d,观察小鼠活动状况,30 d活存率、平均活存时间及保护系数.设照射剂量6.5 Gy组,照射后皮下注射50 mg/（kg·d-1）、100 mg/（kg·d-1）、200 mg/（kg·d-1）的AGE混悬液,观察照射后小鼠外周血血象变化.结果是AGE混悬液在一定剂量范围内[50 ～200 mg/（kg·d-1）]可显著提高辐照小鼠30 d活存率、平均活存天数及保护系数,皮下注射与腹腔注射治疗效果在统计学上则无明显差异.与照射对照组相比,AGE给药组能明显促进急性辐射损伤小鼠外周血血象恢复.说明AGE混悬液对小鼠急性放射病有一定治疗作用,最佳给药方案为照射后皮下注射50 mg/（kg·d-1）的AGE混悬液.

英文摘要：

To investigate the radiation protection effect of AGE suspension liquid in dosage, administration methods on acute radiation-injured mice. and find out the best therapeutic project. Method C57 mice were irradiated by 8.0 Gy 60Coγ-ray, then were injected （Subcutaneous injection or Intraperitoneal injection） with 50 mg/（ kg· d-1）, 100 mg/（ kg · d-L） ,200 mg/（ kg· d-1） of AGE suspension liquid which were continuous injected by 3 days. The activity of mice, the 30 d survival rate, the average survival time and the protection factors were observed. Another group of C57 mice were irradiated by 6.5 Gy 60Coγ-ray, then were injected（ Subcutaneous injection or Intraperitone al injection） with AGE suspension liquid by the same dosage; the mice peripheral blood pictures changed after irradiation were observed. Result A certain dosage of 50 -200 mg/（kg·d-1） AGE suspension liquid could greatly improve the 30 day survival rates ,the average survival time and protection factors of radiation-injured mice. There were no significant difference in therapeutic effects between subcutaneous injection group and intraperitoneal injection group in statistics. Compared with the control group, the groups with AGE can obviously promote the acute radiation injury mice peripheral blood picture. Conclusion The AGE suspension liquid has a certain therapeutic effect on acute radiation-injured mice, the best therapeutic project is （subcutaneous） with 50 mg/（kg·d-1） AGE suspension liquid by 3 days.