为观察复方中药一贯煎的抗炎作用效果,一贯煎全方经过煎煮浓缩后,采用测定角叉菜胶致炎后大鼠左后足的肿胀率,及二甲苯致小鼠耳廓肿胀后耳廓肿胀度,及耳廓肿胀抑制率的方法对一贯煎的抗炎作用效果进行评价。一贯煎浓缩液对大鼠足肿胀有一定的抑制作用,差异明显(p〈0.05),起效时间相对于阳性对照药物稍长持续时间较长(p〈0.05);一贯煎浓缩液对二甲苯致小鼠耳廓肿胀也有一定的抑制作用,差异明显(p〈0.05)。研究结果表明通过行为学观察,可以得知一贯煎具有与阿司匹林相同的抗炎作用。
Aimed at observing the anti-inflammatory effect of Yi Guanjian decoction,after decocting and concentrating all the Chinese herbal medicinal ingredient of Yi Guanjian,the methods had adopted to measure the left hind paw swelling degree of Sprague-Dawley induced by carrageenin and auricular swelling degree and resistant rate caused by dimthylphenanthrene were taken as indexes to analyze the anti-inflammatory function of Yi Guanjian decoction. The concentrated solution of Yi Guanjian has certain inhibitory effect on the foot swelling of rats,and has an obvious difference that compared to the model group( p 〈0. 05),its work time slightly longer than the positive group. The research indicated that Yi Guanjian decoction has some certain anti-inflammatory effect and has equal effect with aspirin.