中文摘要：

目的 了解复合全谷豆粗杂粮膳食干预对空腹血糖受损（IFG）人群胰岛素抵抗及血清中脂肪细胞因子的影响.方法 采用多阶段分层整群随机抽样的方法,于2008年3-9月,在南京市鼓楼、向下、秦淮区的12个社区卫生服务中心选取40 ～ 75岁常住汉族IFG者163例.按准实验设计,将其分为干预组（87例）和对照组（76例）.干预组给予粗杂粮干预和健康教育,对照组仅给予健康教育,干预时间为6个月,干预前后分别进行体检,测量计算其BMI、腰臀比（WHR）;抽取静脉血4 ～5 ml,检测血脂、FBG、空腹胰岛素（FINS）,以及瘦素、载脂蛋白-2（LCN-2）和脂联素（ADP）等脂肪细胞因子的水平,计算胰岛素抵抗指数（HOMA-IR）.采用x2检验分析两组人群各特征的分布差异;采用独立样本￡检验分别比较干预前后两组人群各项指标的差异;采用配对￡检验分别比较两组人群干预前后各项指标的差异;采用两独立样本Wilcoxon秩和检验比较两组人群干预前后各指标差值的差异.结果 干预后干预组的BMI[（24.87±3.69） kg/m2]、FBG[（6.27±0.24） mmol/L]、FINS[（7.14± 1.05） mU/L]、HOMA-IR（1.99±0.31）、瘦素[（13.07 ±2.22） μg/L]、LCN-2[（67.42±18.20）μg/L]水平均低于干预前[（25.16±4.07）kg/m2、（6.40±0.28）mmol/L、（7.32±1.54） mU/L、（2.08±0.45）、（13.43 ±2.52） μg/L、（74.87 ±17.81） μg/L]（t值分别为4.48、7.08、2.05、3.39、3.28、6.36,P值均＜0.05）,而ADP[（5.07±1.51） mg/L]水平高于干预前[（4.92±1.53） mg/L]（t=-2.47,P＜0.05）.干预组干预前后BMI、FBG、FINS、HOMA-IR、瘦素、LCN-2、ADP的差值的中位数（P25,P75）分别为-0.25（-0.68,0.02）kg/m2、-0.08（-0.20,0.00）mmol/L、-0.15（-0.32,0.00）mU/L、-0.07（-0.12,-0.03）、-0.36（-0.77,0.12）μg/L、-5.85（-14.29,-0.71）μg/L、0.15（-0.13,0.36）mg/L,对照组分别为0.00（-0.23,0.29）kg/m2、0.00（-0.03,0.04） mmol/L、-0.01（-0.13,

英文摘要：

Objective To evaluate the effects of compound whole grain-soybean on insulin resistance and serum adipocytokines levels in impared fasting glucose population.Methods According to inclusion and exclusion criteria,163 cases of impared fasting glucose （IFG） Chinese Han population from the age of 40 to 75 years old,were screened from 12 community health centers of three main districts of Nanjing city by the multi-stage cluster and simple randomization method from March to September,2008.The IFG subjects were randomly divided into the intervention group （87 individuals） and control group （76 individuals） by quasi-experimental design.The intervention group was provided with compound whole grain-soybean and health education,while only health education was provided for the control group.Body mass index （BMI）,waist-to-hip ratio （WHR）,lipid profiles,fasting blood glucose （FBG）,fasting insulin （FINS） and homeostasis model assessment of insulin resistance （HOMA-IR）,adipocytokines including leptin,lipocalin 2 （LCN-2） and adiponectin （ADP） levels were measured before and after the half a year intervention period.Chi square test was used to analyze the distribution differences.Two-sample t-test was used to campare the differences of the two groups before and after the half a year intervention period,and paried t-test was used to campare the differences between before and after intervention in the intervention group or control group.Wilcoxon rank sum test was used to campare the differences of all indexes between after and before dietary intervention.Results After dietary interventin for half a year on the IFG population,BMI （（24.87 ± 3.69） kg/m2）,FBG （（6.27 ± 0.24） mmol/L）,FINS （（7.14 ± 1.05） mU/L）,HOMA-IR （1.99 ±0.31）,leptin （（13.07 ± 2.22） μg/L）,LCN-2 （（67.42 ± 18.20） μg/L） of intervention group were decreased significantly compared to the levles of BMI （（25.16 ±4.07） kg/m2）,FBG（（6.40 ± 0.28） mmol/L）,FINS （（7.32 ?