中文摘要：

目的探讨全谷豆复合包改善脂代谢紊乱大鼠胆固醇代谢的可能机制。方法44只雄性SD大鼠随机分为高脂模型组、米面组、全谷豆复合包组和阴性对照组，分别给予对应饲料连续喂养8周。实验前后测定大鼠血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）含量；实验结束后股动脉取血，分离脏器称重，计算脏体比和脂体比，检测血清中Visfatin浓度、肝脏组织中sREBP．2mRNA和LDLRmRNA的表达以及脂肪组织中VisfatinmRNA的表达。结果与高脂模型组和米面组相比，全谷豆复合包组大鼠体重、血清TC、TG、LDL-C水平显著下降（p〈0．05），血清HDL．C水平显著升高（P〈0．05）。全谷豆复合包组大鼠血清Visfatin水平显著低于高脂模型组和米面组（P〈0．05）；与高脂模型组和米面组比较，全谷豆复合包组大鼠肝脏组织中SREBP-2mRNA和LDLRmRNA的表达显著升高（P〈0．05），脂肪组织中VisfatinmRNA的表达明显降低（P〈0．05）。结论全谷豆复合包可以改善高脂膳食诱导的脂代谢紊乱大鼠的血脂和Visfatin水平，可能的机制是全谷豆复合包能增加SREBP-2和LDLR的mRNA表达，降低VisfatinmRNA的表达，经SREBP-2、LDLR和Visfatin途径调控胆固醇的代谢，起到维持TC和LDL-C的正常水平，改善脂代谢紊乱的作用。

英文摘要：

Objective To discuss the possible mechanism of the whole grain-soybean compound package on dyslipidaemia rats. Methods 44 SD rats were randomly divided into four groups： the hyperlipidaemic group, the rice-flour group, the whole grain-soybean compound package group and the negative control group by lipid profiles, fed with corresponding feed for eight weeks. Serum total cholesterol（ TC）, triglyceride （TG）, high density lipoprotein cholesterol（ HDL-C ） and low density lipoprotein cholesterol （ LDL-C ） were measured before and after the test. At the end of the experiment, blood samples weretaken from the femoral artery, the rat organs were collected and weighted. Serum Visfatin levels and SREBP-2 mRNA and LDLR mRNA in the liver were measured. Results Compared with the hyperlipidaemic group and rice-flour group, the body weight, serum TC, TG and LDL-C of whole grain-soybean compound package group were significantly decreased （ P 〈 0. 05 ） , HDL-C was significantly increased （ P 〈 0.05 ）. Visfatin levels were significantly decreased （ P 〈 0.05 ）. Gene expressions of SREBP-2 and LDLR were significantly increased （P 〈 0.05 ）. Gene expression of Visfatin in whole grain-soybean compound package group was significantly lower than that in hyperlipidaemia group and rice-flour group （ P 〈 0.05 ）. Conclusion Whole grain-soybean compound package can improve the serum lipid profiles and Visfatin of rats fed with a high fat diet. The possible mechanism is that the whole grain-soybean compound package can activate the expression of SREBP-2, LDLR and Visfatin. And then enhance the expressing activity of regulate the cholesterol metabolism by SREBP-2,LDLR and Visfatin. Ultimately, to reduce the level of rats＇ cholesterol, and then ameliorate the dyslipidaemia of rats.