中文摘要：

目的观察谷豆复合物、谷豆复合膳食纤维和全谷物玉米膳食纤维（DF）对脂代谢紊乱大鼠血脂及肝脏脂肪酸合成酶（FAS）活性，及其对大鼠肝组织固醇调节元件结合蛋白-1C（SREBP-1C）mRNA表达的影响，比较谷豆复合物、谷豆复合DF与单-谷物DF改善脂毒性效果。方法50只SD大鼠适应性喂养l周后，随机分成阴性对照组、高脂模型组、谷豆复合物组、谷豆复合DF组和玉米DF组；以相应的饲料连续喂养8周后，测定各组大鼠总胆固醇（TC）、甘油三酯（TG）、空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL-C）和FAS等指标，测定各组大鼠肝脏SREBP-1CmRNA的表达。结果与阴性对照组相比，高脂模型组的大鼠血清TC、TG水平显著升高（P〈0．05）；与高脂模型组相比，谷豆复合物组、谷豆复合DF组和玉米DF组大鼠血清TC、TG水平显著降低（P〈0．05）；HDL-C水平显著高于高脂模型组，大鼠肝脏脂肪酸合成酶活性及SREBP-1C的表达显著降低。结论谷豆复合膳食纤维可改善脂代谢紊乱大鼠的血脂水平，降低FAS活性及SREBP-1C的表达水平。

英文摘要：

Objective To observe and compare the effects of grain-bean package, dietary fiber（DF） extracted from grain-bean package, and DF from grain corn on the blood lipids and fatty acid synthase （FAS）activity in high-fat, high-cholesterol feeding induced dyslipidemia rats, and observe its effects on regulation of sterol regulatory element protein- l c（SREBP-lc） mRNA expression in rat liver. Methods Consolidation 50 SD rats of clean grade feeding adaptation for one week, randomly assigned into normal control group, hyperlipidemia model group,grain-bean package group, grain-bean package DF group and grain corn group. Feed with corresponding diets for 8 weeks, and measure the total cholesterol（TC）, triglyceridaemia （ TG）, high density lipoprotein cholesterol （ HDL-C ）, fasting blood glucose （FBG） , FAS, SREBP-lc mRNA of all groups. Result Compared with control group, TC, TG, FBG levels of hyperlipidemia model group were significantly increased（P 〈 0.05）. Compared with model group, TC, TG, FBG levels of grain-bean package group,grain-bean package DF group were significantly decreased, HDL-C levels significantly increased, and activity of FAS, regulation of SREBP-lc were significantly decreased（P 〈 0. 05 ）. Conclusion The Grain-bean package dietary fiber can improve blood lipids levels of dyslipidemia rats, and decrease FAS activity and SREBP-lc mRNA expression.