中文摘要：

目的观察由米面和菰米等不同构成饲料对高脂饲料大鼠血脂、游离脂肪酸（FFA）和瘦素（1eptin）水平的作用，探讨菰米对高脂饲料诱导的脂代谢紊乱大鼠血脂及肝脏脂毒性的作用。方法44只雄性SD大鼠随机分为阴性对照组、高脂模型组、米面组和菰米组；以相应饲料连续喂养8周，测定各组大鼠体重、血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL．C）、FFA和leptin等指标，同时肝脏组织行病理切片检查。结果与阴性对照组相比，高脂模型组和米面组大鼠的血清TC、TG、FFA和leptin水平显著上升（P〈0．05），HDL-C水平显著降低（P〈0．05），肝脏发生脂肪变性；与高脂模型组和米面组相比，菰米组大鼠的血清TC、TG、FFA水平显著下降（P〈0．05），HDL-C水平显著升高（P〈0．05），leptin水平稍低于高脂模型组和米面组，但无显著性差异，肝脏脂肪变性程度显著减轻。结论菰米具有降低高脂饲料诱导的脂代谢紊乱大鼠血脂水平和肝脏脂毒性的作用。

英文摘要：

Objective To study the effects of four kinds of experimental diet, including high fat/cholesterol diet, Chinese wild rice diet, white rice-flour diet and basal diet on the lipotoxicity and disordered lipid metabolism in rats. Methods 44 male SD rats were divided into four groups, the basal group, high fat/cholesterol diet group, white rice-flour group and Chinese wild rice group. All rats of four groups were given different diets. Body weights were measured every week, serum total cholesterol （TC） , triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, free fatty acids （FFA） and leptin concentrations were measured, and liver pathology were observed. Results When compared with the basal diet group, the hyperlipidemic rat model was successfully made in high fat/cholesterol diet group. When compared with the high fat/cholesterol diet group and white rice-flour diet group, the serum TG and TC contents were significantly decreased（P 〈 0.05 ） , and HDL-C concentration significantly increased （ P 〈 0.05 ） in Chinese wild rice group. Moreover, Chinese wild rice group had lower contents of serum and liver FFA than those of the high fat/cholesterol diet group and white rice-flour dietgroup （P 〈 0.05）. Although Chinese wild rice group had a lower serum leptin level than the high fat/cholesterol diet group and white rice-flour diet group, there was no significant differences among the three groups （P 〉 0.05 ）. The conditions of liver cell fatty degeneration in Chinese wild rice group were slight. Conclusion Compared to the white rice-flour diet, Chinese wild rice could improve the lipid metabolism and liver lipotoxicity of hyperlipidemic rats induced by high fat/cholesterol diet.