中文摘要：

目的制备一种载光动力药物的脂质超声微泡,测定物理特性,并观察其对兔VX2肝肿瘤的显影效果及过程。方法采用机械振荡的方法制备载竹红菌素脂质微泡,并测定其粒径大小、分布、Zeta电位和包封率、稳定性及超声辐照后药物释放情况。采用不同超声模式观察微泡在兔VX2肝肿瘤的显像效果及过程。结果载药微泡的粒径为（1052.4±322.7）nm,Zeta电位为＋（21.1±7.4）mV,包封率为（88.1±4.6）%,超声辐照能够促使微泡释放药物,对兔VX2肝肿瘤的显影效果好。结论载竹红菌素脂质微泡包封率高、微泡能够释放药物、显像好,符合理想的药物载体,为实时监控下的体内定位光动力治疗疾病提供了一种新的思路。

英文摘要：

Objective A kind of microbubbles containing hypocrellin were preparated and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery. Methods The mierobubbles containing hypocrellin （HA） were prepared by mechanical vibration. The resulting microbubbles containing hypocrellin were studied for size, Zeta potential, drug en trapment efficiency, drug release percentage. The enhancement of ultrasound imaging in vivo was assessed. Results The mean diameter of preparing microbubbles containing hypocrellin was （1052.4±322.7）nm. The Zeta potential was ＋ （21.1±7.4）mV. The drug entrapment efficiency was （88.1±4.6）%. Different intensity ultrasound irradiatedmicrobubbles containing hypocrellin, which ruptured microbubbles and released drugs. The imaging of the rabbit liver and tumor could be enhanced obviously. Conclusion The self-made lipid microbubbles containing HA are consistent to the standard of ideal drug vehicle. The microbubbles might be a useful tool for deliver chemotherapeutic drug, and thus providing a novel strategy for diagnose and photodynamic therapy of the tumor.