中文摘要：

目的：研究益肾达络饮对复发-缓解型EAE小鼠发病率、发病时间、复发率、神经功能评分及病理特征的影响。方法：用HE染色和Luxol fast blue染色观察EAE小鼠的病理特征。结果：中药组EAE小鼠的复发率（14.27%）低于模型组（62.5%）;免疫后第21天神经功能评分,中药组（1.86±0.40）低于模型组（3.13±0.69）;免疫后第61天神经功能评分,中药组（0.86±0.55）低于模型组（2.75±0.73）,差异有统计学意义（P〈0.05）。结论：益肾达络饮能降低EAE小鼠的复发率、神经功能评分,减轻炎性细胞浸润和髓鞘脱失,但其作用机制需要进一步研究。

英文摘要：

Objective：To investigate the effect of Yishen Daluo Decoction on the incidence, onset, relapse rate, score of neural function and pathological feature in the mice with relapsing - remitting experimental autoimmune encephalomyelitis. Methods ： He- matoxylin - eosin staining and Luxol fast blue staining were used to observe the pathological feature in the mice with experimental autoimmune encephalomyelitis. Results： The relapse rate of the treated group （14.27%） was less than the model group＇s （62.5%） ;the score of neural function of the treated group（ 1.86 ±0.40）was less than the model group＇s （3.13 ±0.69） at the day 21 after immunization; the score of neural function of the treated group （0.86 ±0.55 ）was less than the model group＇s （2.75 ±0.73 ） at the day 61 after immunization （ P 〈 0. 05 ）. Conclusion ： After treatment with Yishen Daluo Decoction, the relapse rate and the score of neural function of the mice with experimental autoimmune encephalomyelitis are reduced, the infiltration of inflammatory cells and the loss of myelin are alleviated, but the effective mechanism of Yishen Daluo Decoction needs to be further explored.