中文摘要：

目的探讨血压昼夜节律异常与肾损害的关系。方法收集2004—2008年在我院内一科进行过24 h动态血压监测的住院患者的动态血压数据及相关资料,并进行统计分析。结果 242例患者根据夜间收缩压较日间收缩压下降幅度分为杓型85例（35.1%）,非杓型103例（42.6%）,反杓型42例（17.4%）,超杓型12例（4.9%）,4型患者的血尿素氮、血肌酐水平间差异均有统计学意义（P值分别为0.004和0.003）,而血尿酸水平间差异无统计学意义（P=0.22）。进一步分析发现,仅在高血压患者中,4型患者的血肌酐水平间差异有统计学意义（P=0.02）;而在血压正常者中,4型患者的血肌酐水平间差异无统计学意义（P=0.18）。结论高血压患者的血压昼夜节律异常与肾脏损害有关,以反杓型和超杓型者最为显著。

英文摘要：

Objective To investigate the relationship between circadian rhythm of blood pressure and renal damage..Methods Clinical data of patients who underwent 24h ambulatory blood pressure monitoring from 2004 to 2008 in medical department of our hospital were collected and analyzed. Results In the 242 inpatients,there was significant difference between dippers（n=85）,non-dippers（n=103）,reverse dippers（n=42） and extreme dippers（n=12） in serum urea nitrogen and creatinine（P0.05）,but there was no significant difference in blood uric acid（P=0.22）.Further analysis showed that statistical difference in creatinine between the four types of patients was only shown in hypertensive patients（P=0.02）,but no difference was shown in those who had normal blood pressure（P=0.18）. Conclusion Abnormal circadian rhythm of blood pressure is associated with renal damage in hypertensive,with adverse dippers and extreme dippers having the most serious renal damage.