中文摘要：

阿尔茨海默病（Alzheimer’s disease,AD）是老年人最常见的痴呆类型,其主要的病理变化包括胞外β淀粉样蛋白（β-amyloid protein,Aβ）沉积,老年斑（SP）形成;神经元丢失、神经元细胞内出现神经元纤维丝缠结（NFT）。3x Tg-AD小鼠作为首个能同时产生淀粉样斑块和神经元纤维缠结的动物模型被广泛用于AD的研究,本文旨在针对3x Tg-AD小鼠相关药理学研究进展作一综述,包括3x Tg-AD小鼠基本描述和以3x Tg-AD小鼠为研究对象的多种药物研究的简要介绍。

英文摘要：

Alzheimer＇s disease（ AD） is the most common type of dementia in elderly people. The main pathological changes include extracellular Aβ protein deposition,formation of senile plaques（ SPs）,neuronal loss and intracellular neurofibrillary tangles（ NFTs）. 3x Tg-AD mice have been widely used in AD research as the first kind of animal model which can generate both amyloid plaques and neurofibrillary tangles. This paper aims at summarizing the pharmacological research related with 3x Tg-AD mice,including basic introduction of 3x Tg-AD mice and pharmacological studies of many kinds of drugs on the mice.