中文摘要：

阿尔茨海默病（Alzheimer＇sdisease，AD）是老年人中最常见的神经退行性疾病，以过度磷酸化tau蛋白为核心形成的神经原纤维缠结为AD的主要病理特征之一。近年来对tau蛋白磷酸化的研究备受关注。在AD的实验研究中，探索理想的AD动物模型对于明确AD的病因、发病机制及药物的研发等方面起关键作用。本文对Tau蛋白磷酸化致AD主要动物模型的研究进展进行了综述，包括Tau转基因动物模型、激酶和磷酸化酶系统失衡致Tau蛋白过度磷酸化损伤模型、降低Tau蛋白糖基化致Tau过度磷酸化模型等。

英文摘要：

Alzheimer＇s disease （AD） is a progressive and fatal neurodegenerative disorder. The aggregation of hyperphosphorylated tau into neurofibrillary tangles （NFT） is a hallmark in the histopathology of AD. A number of mouse models have been created to study the major neuropathological mechanism and the drug research. We provide here some considerations for selecting a mouse model of AD, including tau transgenic mice, hyperphosphorylated tau animal model induced by imbalance of the activities of kinases and phosphatases, and animal model of hyperphosphorytated tau induced by decreasing O-GlcNAcylation.