中文摘要：

目的观察人工肝支持系统对肝衰竭患者血清IL-6、TNF-α、IL-12p70和INF-γ的清除效果．进一步探讨人工肝支持系统在肝衰竭治疗中的意义。方法采用CBA法检测63例肝衰竭患者（29例为人工肝结合内科治疗组．34例为内科治疗组1治疗前后细胞因子水平．比较它们在治疗前后的变化。结果 肝衰竭患者细胞因子水平治疗前、后均高于健康对照组（均P〈0．05），有效组治疗后，IL-6、TNF-α水平均较治疗前下降明显（均P〈0．05），且人工肝有效组下降的更明显，IL-12p70和IFN-γ有一定水平的上升，人工肝组IL-12p70水平治疗前与治疗后差异有统计学意义（P〈0．05），IFN-γ水平差异无统计学意义（P〉0．05），内科有效组虽有上升，但差异无统计学意义（均P〉0．05）；无效组治疗后。IL-6、TNF-α水平保持较高水平．治疗前后差异无统计学意义（均P〉0．05），IL-12p70和IFN-γ治疗后水平下降，但前后差异无统计学意义（均P〉0．05）。结论人工肝治疗后对IL-6、TNF-α均有不同程度的清除作用．而IL-12p70和IFN-γ却有一定程度的升高。从而减轻免疫反应对肝细胞的损害，有助于改善肝衰竭患者的预后。

英文摘要：

Objective To observe dynamically the level of cytokine in the peripheral blood in patients with liver failure received artificial liver support system and/or medical treatment. Methods According to the treatment mode 63 patients with liver failure were divided into 2 groups： 29 cases treated by combining artificial liver support system with medical treatment （combined group） and 34 cases by medical treatment group （medical group）. The levels of serum cytokines were measured by Cytometric bead array. Results The level of serum cytokine of liver failure patients was significantly highter than that of healthy controls before and after treatment （P〈0.05）, the levels of IL-6 and TNF-a were decreased obviously and level of IL-12p70 was increased obviously in the effective groups after treatment, than those of before treatment （P〈0.05） , the level of INF-γ/was increased but no significant difference between the groups （P〉0.05）. As to the ineffective groups, the levels of IL-6 and TNF-α were no significant difference between before and after treatment （P〈0.05）, and the levels of IFN-γ/and IL-12p70 were decreased but no significant difference （/9〉0.05）. Conclusion IL-6 and TNF-α are eliminated to some extent after the treatment of er, IL-12p70 and INF-γ/are increased to some extent, which alleviate the ALSS, damage to liver cells caused by immunoreaction, and improve the prognosis of hepatic failure patients.