中文摘要：

目的：观察红芪黄酮对肺间质纤维化模型大鼠肺功能的影响，并探讨其作用机制。方法：取SPF级Wistar大鼠72只，按照随机数字表法分为空白对照组、模型组、强的松组及红芪黄酮低、中、高剂量组，每组12只。采用喉镜引导下气管插管注入博莱霉素法复制肺间质纤维化大鼠模型，检测肺功能。结果：红芪黄酮低、中、高剂量能不同程度改善肺间质纤维化疾病大鼠模型肺功能指标。结论：红芪黄酮具有改善肺纤维化大鼠肺功能的作用。

英文摘要：

Objective ：To study the effect of flavonoids from Hedysari Radix on pulmonary functions of pulmonary fibrosis rat and its mechanism. Methods ： 72 Wistar rats were randomly divided into 6 groups ： blank control group, model group, prednisone group, Hedysari Radix flavonoids low, medium and high dosage group. The rat model was established by propelling bleomycin into bronchial tree through endotracheal intubation with laryngoscope. The pulmonary fanctions were measured. Results： Hcdysari Radix flavonoids could normalize the pulmonary functions of rats with bleomycin-induced pulmonary fibrosis. Conclusion：Hedysari Radix flavonoids can inhibit the process of pulmonary fibrosis.