中文摘要：

目的：研究芎冰微乳制剂在兔体内的药动学特征。方法：芎冰微乳质量静脉注射给药后,采用高效液相测定不同时间点TMP的血药浓度,用DAS2.1数据处理软件计算药动学参数。结果：TMP体内质量浓度在0.062～12.4 mg.L-1（R2=0.998）呈良好的线性关系,其血药浓度曲线符合二室模型,其主要药动学参数t1/2α=15.617 mint,1/2β=49.171 min,V=0.509 L.kg-1,CL=0.014 L.min-1.kg-1,AUC（0-∞）=222 063.235μg.min.L-1,MRT（0-∞）=30.841 min。结论：本实验建立的方法简单,线性、精密度、回收率良好,专属性强,可用于川芎嗪体内药动学研究,并明确了芎冰微乳注射给药在新西兰兔体内的药动学特征。

英文摘要：

Objective：To investigate pharmacokinetics of Xiongbing Microemulsion in rabbit blood.Method：The plasma concentration of tetramethylpyrazine（TMP） was determined by HPLC after i.v.The data were processed by DAS 2.1 software to calculate the pharmacokinetic parameters.Result：The calibration curve was linear in the range of 0.062-12.4 mg·L-1（R2=0.998）.The measured pharmacokinetics of free TMP concentration fitted open two compartment model after i.v.The main pharmacokinetic parameters for TMP were as follows：t1/2α was 15.617 min;t1/2was 49.171 min;and V was 0.509 L·kg-1;CL was 0.014 L·min-1·kg-1;AUC（0-∞）was 222 063.235 μg·min·L-1;MRT（0-∞）was 30.841 min.Conclusion：With good linearity,precision and recovery,the method is sensitive and simple,and suitable for pharmacokinetic study and the research of TMP.The pharmacokinetic characteristics of TMP in rabbits were understood.