中文摘要：

目的：以磷酸川芎嗪为模型药物，探讨运用泊洛沙姆P407（P407）制备鼻用温敏型原位凝胶的可行性。方法：采用搅拌转予法测定不同处方磷酸川芎嗪原位凝胶的胶凝温度（胶凝温度：T）；在不同温度下，以旋转式黏度计测定加入不同浓度辅料后P407溶液的黏度，以考察黏度随温度的变化规律。结果：P407溶液浓度越高，T越低；辅料的加入可以使P407溶液T升高，而处方药物和等渗调节剂（O．9％NaCl）使P407溶液T降低。当温度升高时，P407黏度增大，而辅料的加入会使P407黏度突变点的温度升高，黏度变小。结论：通过调节P407溶液的浓度或加入一定量辅料的方法，可以使TMPP原位凝胶在鼻腔温度（33℃左右）下胶凝，从而达到增大生物利用度和减少给药流失的要求。

英文摘要：

OBJECTIVE By using tetramethylpyrazine phosphate （TMPP）as a model drug, to stady the feasibility of preparation of nasal thermosensitive gels of TMPP. METHODS The mixing rotor was used to determine the gelatin temperature（gelatin temperature：T） of different thermosensitive gels of TMPP. By the rotary viscometer, it was evaluated the viscosities of P407 solution under different temperatures. RESULTS The higher the concentration of P407, the lower the T of gel. Accessories could make T of P407 solution higher, however,TMPP and isotonic regulator （0. 9% NaCl）induced the T of P407 gel decreased. When the temperature rose, the viscosity of P407 increased. And with the additions of accessories, the T of P407 increased, but the viscosity decreased. CONCLUSION By adjusting the concentration of P407 or adding a certain amount of accessories, thermosensitive gels of TMPP could be gelled at about 33 ℃, which will increase the bioavailability and reduce drug wastage.