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中文摘要：
通过已建立的抗朊病毒药物筛选模型,研究钩藤提物对酵母朊病毒细胞模型的治疗作用。通过在液体培养基中加入钩藤提取物的方式,利用酵母朊病毒[PSI＋]表型分析方法和蛋白水平的半变性琼脂糖凝胶电泳技术分析钩藤提取物抗朊病毒的效果。结果显示,钩藤醇提取物对感染朊病毒酵母[PSI＋]作用5d后的治愈率为5%,而水提取物没有治疗效果。蛋白水平检测进一步说明钩藤醇提取物具有抗酵母朊病毒的作用。
英文摘要：
In this study, we explored the role of extracts of uncaria on yeast prion [PSI＋] by established an- ti-prion drug screening model. The curing effects of extract from uncariaon on yeast prion were investigated using addition of reasonable concentration of Chinese medicine composition to the medium. The phenotype system of blot were uncarla on showed th yeast prion [PSI＋] and the semi-denaturing agarose gel electrophoresis combined with Western used to assay effects of uncariaon on [PSI＋ ]. Results showed the cure rate of alcohol extracts of yeast prion [PSI＋] can reach 5%,while the water extract had no effect. Protein level detection at alcohol extract of uncaria has a certain curing effect on yeast prion[PSI＋ ].
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