中文摘要：

目的探讨穴位埋线联合α-干扰素治疗HBeAg阳性慢性乙型肝炎患者的有效性及安全性。方法将350例慢性乙型肝炎患者随机分为治疗组及对照组各175例,均给予α-干扰素500万IU隔日1次肌肉注射;治疗组在此基础上加用穴位埋线治疗,每2周1次,4次为1个疗程,连续治疗3个疗程。观察2组治疗前后T淋巴细胞亚群、症状体征及肝功能变化情况,统计2组HBV DNA、HBs Ag、HBeAg阴转率,HBeAg/HBe Ab转换率,临床疗效和不良反应发生情况。结果治疗24周及48周后,2组症状体征总积分均明显降低（P均〈0.05）,且治疗组评分明显低于对照组（P〈0.05）;2组治疗后ALT、AST、TBil均基本恢复正常,2组比较差异无统计学意义（P〉0.05）;治疗48周后,治疗组CD3^＋、CD4^＋、CD8^＋水平及CD4^＋/CD8^＋均较治疗前明显升高（P均〈0.05）,对照组CD3^＋、CD8^＋、CD4^＋/CD8^＋明显升高（P均〈0.05）,而CD4^＋水平无明显变化（P〉0.05）;治疗组CD4^＋水平及CD4^＋/CD8^＋明显高于对照组（P均〈0.05）。治疗组HBV DNA、HBs Ag、HBeAg阴转率及HBeAg/HBe Ab转换率均明显高于对照组（P均〈0.05）,总有效率明显高于对照组（P〈0.05）。结论α-干扰素联合穴位埋线疗法治疗HBeAg阳性慢性乙型肝炎,可以有效改善患者的免疫功能状态、肝功能及临床症状及体征,提高抗病毒有效性。

英文摘要：

Objective It is to investigate the efficacy and safety of the therapy with acupoint catgut embedding combined with interferon-α in chronic hepatitis B（CHB） patients with HBeAg-positive. Methods 350 cases of chronic hepatitis B were randomly divided into treatment group and control group with 175 cases in each group. All patients in the two groups were treated with interferon-α 5 million units,tertian intramuscular injection. On the based of above treatment,the patients of treatment group was treated with acupoint catgut embedding therapy,once every 2 weeks,4 times for a course of treatment,continuous treatment of 3 courses. The changes of T lymphocyte subsets,symptoms and signs,liver function were observed before and after treatment in two groups,and the negative rate of HBV DNA,HBs Ag,HBeAg,the conversion rate of HBe Ab/HBe Ab,and the clinical curative effect and side effect were analyzed. Results After treated for 24-and 48-week,the total scores of symptoms and signs of the two groups were significantly decreased（all P〈0. 05）,and the score of the treatment group was significantly lower than that of the control group（P〈0. 05）. The levels of ALT,AST,TBil basically returned to normal after treatment,there was no significant difference between the two groups（all P〉0. 05）; after treated for 48-week,the levels of CD3^＋,CD4^＋,CD8^＋and CD4^＋/CD8^＋in the treatment group and the levels of CD3^＋,CD8^＋and CD4^＋/CD8^＋in the control group were significantly higher than before treatment（all P〈0. 05）,the levels of CD4^＋and CD4^＋/CD8^＋in the treatment group were significantly hihger than those in the control group（all P〈0. 05）. The negative rate of HBV DNA,HBs Ag,HBeAg,and the conversion rate of HBe Ab/HBe Ab of the treatment group were significantly higher than those of the control group（all P〈0. 05）,and the total effective rate were significantly higher than the control group（P〈0. 05）. Conclusion Acupoint catgut embedding combined with interferon-α in th