目的:评估肾移植患者健康状况,并与血液透析患者和健康者进行比较,同时对接受两种免疫抑制剂治疗的肾移植患者的健康状况进行比较。方法:①选择2005-06/12南方医科大学南方医院。肾移植科门诊就诊的肾移植患者300例。皆因终末期肾脏疾病进行肾移植,且移植后肾功能稳定。纳入同期本院透析中心接受血液透析的患者100例。皆因终末期肾脏疾病,进行透析治疗,且稳定透析半年以上。纳入同期南方医科大学进行健康体检的教职员工100名。上述纳入对象均自愿接受量表评估。②采用自测健康评定量表评估纳入对象健康状况。该量表包括个体健康的生理、心理和社会3个子量表,3个评定子量丧分和自测健康评定量表修订版总分的理论最高值分别为170,150,120,440分;理论最小值均为0。分数越高,表明自测健康状况越好。③采用单因素方差分析比较多组间计量资料差异,进一步两两比较采用q检验;两组间比较采用t检验。结果:分别发给肾移植患者、血液透析患者、健康者300和100及100份,收回填写完完整、准确的量表分别为228,61,89份,其中接受环孢素和他克莫司治疗的肾移植患者分别为141和87例。①肾移植患者、血液透析患者和健康人间自测健康评定量表评分比较:健康人自测健康评定量表总分最高(343.74±45.60)分,其次是肾移植患者(323.26±51.95)分,得分最低的为血液透析患者(264.00±61.18)分。肾移植患者生理、心理和社会健康3个方面、9个维度及罱表总分明显高于血液透析患者(P〈0.05-0.01)。肾移植患者自测健康评定量表中日常生活功能、心理症状与负向情绪、角色活动和社会资源与社会接触得分接近于健康人,身体症状与器官功能、身体活动功能、正向情绪、认知功能、社会支持上得分明显低于健康?
AIM: To evaluate the self-rated health status of kidney transplantation patients, compare between the hemodialysis patients and healthy persons, at the same time, to compare the health status of kidney transplantation patients treated with two different immunosuppressants. METHODS: ①From June to December 2005 totally 300 kidney transplantation outpatients with stable kidney function after transplantation, who were treated with kidney transplantation, because of end-stage renal disease (ESRD), from Department of Kidney Transplantation in Nanfang Hospital, and 100 hemodialysis patients, who were treated with hemodialysis for over half a year, because of ESRD, from Blood Purification Center of the same hospital of Southern Medical University, were enrolled. At the same time, 100 staffs, who were treated with body examination in Southern Medical University, were selected. Above-mentioned subjects all agreed to participant in the assessment voluntarily. ②The self, rated health status was assessed with Self-rated Health Measurement Scale (SRHMS V1.0). The SRHMS V1.0 was consisted of 3 subscales of physical health, psychological health and social health, The highest scores of physical health, psychological health, social health and the total score of SRHMS V1.0 were 170, 150, 120 and 440 points, respectively, whereas the lowest score was 0 point. The higher score of SRHMS V1.0 indicated the better self-rated health status. ③The single factor variance analysis was used to compare the difference of measurement data among multiple groups, Pairwise comparison was performed with q test. Comparison between two groups was conducted with t test. RESULTS: Totally 300, 100 and 100 questionnaires were sent out for kidney transplantation outpatients, hamodialysis patients and healthy persons, respectively, and 228, 61 and 89 full-filled exact questionnaires were retrieved. There were 141 and 87 kidney transplantation .patients that received cyclosporin and tacrolimus. ①Comparison among kidney transplantation o