欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
Nucleic acid aptamers, which are generated by a novel technique called SELEX(systematic evolution of ligands by exponential enrichment), have recently atracted signiicant atention in the ield of early detection and treatment of cancer based on their numerous merits, such as high ainity, high speciicity,small size, litle immunogenicity, stable structures, and ease of chemical modiication. Furthermore,aptamers can gain more lexibility as cancer cell targeting tools when conjugated to nanomaterials,including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric nanoparticles.We discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with diferent nanomaterials.
英文摘要：
Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic evolution of ligands by exponential enrichment), have recently attracted significant attention in the field of early detection and treatment of cancer based on their numerous merits, such as high affinity, high specificity, small size, little immunogenicity, stable structures, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric nanoparticles. We discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with different nanomaterials.
同期刊论文项目
同项目期刊论文
Versatile DNAzyme-Based Amplified Biosensing Platforms for Nucleic Acid, Protein, and Enzyme Activit
Development of a highly robust solid phase microextraction fiber based on crosslinked methyl methacr
Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on nitrogen do
A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocatio
A flexible trilineardecomposition algorithm for three-way calibration based on the trilinear compone
Noncovalent assembly of reduced graphene oxideand alkyl-grafted mesoporous silica: an effective drug
Targeted Intracellular Controlled Drug Delivery and Tumor Therapy through in Situ Forming Ag Nanogat
DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intr
Rapid andsimultaneous determination of five vinca alkaloids in catharanthus roseus andhuman serum us
A combination of positive dielectrophoresis driven on-line enrichment and aptamer-fluorescent silica
Redox-responsive degradable honeycomb manganese oxide nanostructures aseffective nanocarriers for in
Ultrasensitive Detection of Single Nucleotide Polymorphism inHuman Mitochondrial DNA Utilizing Ion-M
Magnetic graphene oxide modified with choline chloride-based deep eutectic solvent for the solid-pha
Ultrasensitive Electrochemical Detection of Nucleic Acids Based on the Dual-Signaling Electrochemica
Magnetic-graphene based molecularly imprinted polymer nanocomposite for the recognition of bovine he
Poly(thymine)-Templated Copper Nanoparticles as a Fluorescent Indicator for Hydrogen Peroxide and Ox
Analysis of perfluorooctane sulfonate and perfluorooctanoic acid with a mixed-mode coating-based sol
Self-assembly synthesis of a hierarchical structure using hollow nitrogen-doped carbon spheres as sp
The prepartion of magnetic molecularly imprinted nanoparticles for the recognition of bovine hemoglo
Development of spiropyran-based electrochemical sensor via simultaneous photochemical and target-act
Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation a
Intra-molecular G-quadruplex structure generated by DNA-templated click chemistry: “Turn-on” fluores
A novel mix-and-read fluorescent strategy for turn-on probing kinase activity based on aptameric pep
Two novel zeolitic imidazolate frameworks (ZIFs) as sorbents for solid-phase extraction (SPE) of pol
An aptamer-based quartz crystal microbalance biosensor for sensitive and selective detection of leuk
Enhanced nonenzymatic sensing of hydrogen peroxide released from living cells based on Fe3O4/self-re
The adenine DNA self-assembled of pH- and near-infrared-responsive gold nanorods vehicle for chemoth
Gold nanorod-seeded synthesis of Au@Ag/Au nanospheres with broad and intense near-infrared absorptio
Co-loading of coralyne and indocyanine green into adenine DNA-functionalized mesoporous silica nanop
Ligation–rolling circle amplification combined with γ-cyclodextrin mediated stemless molecular beaco
Amplified electrochemical detection of protein kinase activity based on gold nanoparticles/multi-wal
Remote-controlled drug release from graphene oxide-capped mesoporous silica to cancer cells by photo
Label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-tri
Visual and Portable Strategy for Copper(II) Detection Based on a Striplike Poly(Thymine)-Caged and M
Target-catalyzed dynamic assembly-based pyrene excimer switching for enzyme-free nucleic acid amplif
Nanometer-sized manganese oxide-quenched fluorescent oligonucleotides: an effective sensing platform
Concatemeric dsDNA-Templated Copper Nanoparticles Strategy with Improved Sensitivity and Stability B
A Versatile Activatable Fluorescence Probing Platform for Cancer Cells in Vitro and in Vivo Based on
Au@Ag/Au nanoparticles assembled with activatable aptamer probes as smart “nanodoctors” for image-gu
pH-responsive polymer/mesoporous silica nano-container through an acid cleavable linker for intracel
Isothermal Nucleic Acid Amplification Strategy by Cyclic Enzymatic Repairing for Highly Sensitive Mi
Magnetic separation–enrichment-mediated signal amplification for a simple and sensitive fluorometric
Color Di？erence Ampli？cation between Gold Nanoparticles in Colorimetric Analysis with Actively Contr
Molecular Engineering of a TBET-Based Two-Photon Fluorescent Probe for Ratiometric Imaging of Living
Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO2 Nanosheet–Aptamer Nano
Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for phot
A ratiometric electrochemical biosensor for sensitive detection of Hg2+ based on thymine-Hg2+-thymin
Simultaneous electrochemical determination of hydroquinone, catechol and resorcinol at nitrogen dope
Highly-selective electrochemical determination of catechol based on 3-aminophenylboronic acid-3,4,9,
Amplified impedimetric DNA sensor based on graphene oxide–phenylboronic acid for sensitive detection
A ratiometric electrochemical aptasensor for sensitive detection of protein based on aptamer-target-
Intelligent layered nanoflare: “lab-on-a nanoparticle” for multiple DNA logic gate operations and ef
Design of functional guanidinium ionic liquid aqueous two-phase systems for the efficient purificati
Interference-free determination of Indole-3-Acetic acid in two real systems using second-order calib
Quantitative study of state switching in proteins using a single probe combined with trilinear decom
Magnetic solid-phase extraction of proteins based on hydroxy functional ionic liquid-modified magnet
An efficient ratiometric fluorescent excimer probe for hypochlorite based on a cofacial xanthene bri
An aggregated perylene-based broad-spectrum, efficient and label-free quencher for multiplexed fluor
Chemometrics-enhanced high performance liquid chromatography -diode array detection strategy for sim
Simultaneous determination of phenolic antioxidantsinedible vegetableoils by HPLC-FLD assisted withs
Direct quantitative analysis of aromatic amino acids in human plasma by four-way calibration using i
STIP overexpression confers oncogenic potential tohuman non-small cell lung cancer cells by regulati
Self-assembledmultifunctional DNA nanoflowers for the circumvention of multidrug resistancein target
Efficient Two-Photon Fluorescent Probe for NitroreductaseDetection and Hypoxia Imaging in Tumor Cell
Sensitive and Rapid Detection of Endogenous Hydrogen Sulfide Distributing in Different Mouse Viscera
Simultaneous determination of naphazoline and pyridoxine in eye drops using excitation–emission matr
Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted antica
DNA-mediated supercharged fluorescent protein/ Q1 Q2 graphene oxide interaction for label-free fluor
Solving signal instability to maintain the second-order advantage inthe resolution and determination
Chemometrics-assisted determination of amiloride and triamterene in biological fluids with overlappe
Through-Bond Energy Transfer-Based Ratiometric Two-Photon Probe for Fluorescent Imaging of Pd2+ Ions
Silver Nanoparticle Gated, Mesoporous Silica Coated Gold Nanorods (AuNR@MS@AgNPs): Low Premature Rel
Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ult
Hemicyanine-based High Resolution Ratiometric near-Infrared Fluorescent Probe for Monitoring pH Chan
Iodide-Responsive Cu？Au Nanoparticle-Based Colorimetric Platform for Ultrasensitive Detection of Tar
Masking agent-free and channel-switch-mode simultaneous sensing of Fe3+ and Hg2+ using dual-excitati
Preparation of magnetic chitosan and graphene oxide-functional guanidinium ionic liquid composite fo
A ratiometric electrochemical biosensor for sensitive detection of Hg2+ based on thymine–Hg2+–thymin
PlatinumNanoparticles Encapsulated in Nitrogen-Doped Mesoporous Carbonsas Methanol-Tolerant Oxygen R
A new ratiometric electrochemical sensor for sensitive detection of bisphenol A based on poly-b cycl
Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone ace
A universal platform for building molecular logic circuits based on a reconfigurable three dimension
Fast quantitative analysis of four tyrosine kinase inhibitors in different human plasma samples usin
DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissu
Programmed packaging of mesoporous silica nanocarriers for matrixmetalloprotease 2-triggered tumor t
A highly sensitive electrochemiluminescence assay for protein kinase based on double-quenching of gr
Glutathione-Mediated Degradation of Surface-Capped MnO 2 for Drug Release from Mesoporous Silica Nan
Phosphorylation-Mediated Assembly of a Semisynthetic Fluorescent Protein for Label-Free Detection of
Multi-targeted interference-free determination of ten β-blockers in human urine and plasma samples b
A pH-responsive polymer/mesoporous silica nano-container linked through an acid cleavable linker for
Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA C
A new strategy based on cholesterol-functionalized iron oxide magnetic nanoparticles for determinati
A superquenched DNAzyme-perylene complex: a convenient, universal and low-background strategy for fl
A highly sensitive and reductant-resistant fluorescent probe for nitroxyl in aqueous solution and se
A rhodamine-appended water-soluble conjugated polymer: an efficient ratiometric fluorescence sensing
Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy
Alabel-freeDNAzyme fluorescencebiosensorforamplified detection of Pb2+-based oncleavage-induced G-qu
Selective Colorimetric Detection of Hydrogen Sulfide Based on Primary Amine-Active Ester Cross-Linki
Quantitative investigation of the dynamic interaction of human serum albumin with procaine using a m
Screening of DNA Aptamers against Myoglobin Using a Positive and Negative Selection Units Integrated
Magnetic multiwall carbon nanotubes modified with dual hydroxy functional ionic liquid for the solid
Selective Tracking of Lysosomal Cu2+ Ions Using Simultaneous Target- and Location-Activated Fluoresc
Ultrasensitive and Highly Selective Detection of Bioaccumulation of Methyl-Mercury in Fish Samples v
DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of mi
位置：