中文摘要：

目的：探讨普瑞巴林对神经病理性痛大鼠行为学的影响。方法：建立大鼠神经病理性痛模型（CCI模型）,取40只雄性Sprague-Dawley大鼠随机分成4组,Ⅰ组为空白对照组,Ⅱ组为假手术组,Ⅲ组为CCI＋普瑞巴林治疗组,Ⅲ组在术后第1天开始灌胃给予3mg/kg普瑞巴林,Ⅳ组为CCI手术组。分别于术前0d及术后1d、3d、5d、7d、9d、11d、14d以热辐射法测定热缩足反射潜伏期（Paw withdrawal thermal latency,PWTL）,观察神经病理性痛大鼠行为学变化。结果：术后14d,Ⅳ组和I、Ⅱ、Ⅲ组相比较,大鼠后爪的热痛敏阈值明显降低（P〈0.01）;I、Ⅱ、Ⅲ组之间相比,大鼠后爪的热痛敏阈值差异没有显著性（P〉0.05）。结论：普瑞巴林可以缓解神经病理性痛大鼠的慢性神经病理痛行为学表现。

英文摘要：

Objective：To investigate the effects of Pregabalin on neuropathic pain of chronic constriction injury （CCI） rats.Methods：CCI rat model was prepared.Sprague-Dawley male rats （n=40 ） were randomly divided into blank group （I） , sham-operated group （II）, CCI ＋ Pregabalin group （III） , and CCI group （IV） .Thermal withdrawal latency was measured to detect the changes of neuropathic pain behavior in CCI rats on the day 0 , 1 , 3 , 5 , 7 , 9 , 11 , 14 after operation.Results：At day 14 after operation , the paw withdrawal thermal latency in group Ⅳ were lower than those in group I, II,and III （P0.01）.The paw withdrawal thermal latency showed no significant difference among group I, II and III （P0.05）.Conclusions：Pregabalin can release neuropathic pain in CCI rats.