中文摘要：

采用预聚-扩链-中和-分散溶解法，一步合成出聚氨酯（PU）水溶液，运用凝聚相分离法合成出PU微胶囊。以新鲜人血与3．8％的枸橼酸钠溶液配制成抗凝血，将PU材料与血液接触，测定其血小板消耗率；采集新鲜人血，与血液保存液（ACD）配制成ACD血液，使PU材料与ACD血液接触，动态地观察材料对凝血时间的影响，测定动态凝血时间；同样以新鲜人血与2％草酸钾溶液配制威抗凝血，用生理盐水稀释制得新鲜稀释抗凝血，测试PU材料与血液接触一定时间后，血液中红细胞释放出的血红蛋白量，得该种材料的溶血率，发现PU材料的血小板消耗率为17．99％，符合与血液接触材料使用的要求；所测PU材料的动态凝血时间为74min（接近阴性对照长的动态凝血时间78min），说明材料引发的凝血少，具有较好的抗凝血性能；PU材料的溶血率为2．17％（小于规定值5％），该材料对红细胞的破坏作用很小：由此说明PU微胶囊材料具有很好的血液相容性．可以作为与血液接触的植入材料.

英文摘要：

The PU water solutions were synthesized by combining prepolymerization,chain-extension,neutralization and dispersion-diffluence methods in one step. And the PU microcapsulcs were synthesized by coacervation phase separation method. The platelet wear down ratio was measured by contacting PU material with anti-cruor mixed fresh human blood with 3.8% sodium citrate solution. The ACD blood was prepared by fresh human blood and ACD（acid-dextrose）. And the moving cruor time was measured by contacting PU material with ACD blood. The diluted fresh anti-cruor was prepared by fresh human blood ,2% potassium oxalate solution and physiological salt solution. The haemolytic ratio was measured by by contacting PU material with diluted fresh anti-cruor through calculating blood-red protein releasing from red blood cell. The platelet wear down ratio is 17.99% ,the moving cruor time is 74 rain（ near to negative moving cruor time） ,and the haemolytic ratio is 2. 17% （ lower than 5% of standard value）. Therefore,the blood compatibility of PU material is very well from the tests.