中文摘要：

通过离子凝胶法制备出球形完好的海藻酸钠-胰蛋白酶微球。红外分析表明,微球中凝胶基质通过海藻酸钠的—COO-与Ca2＋发生静电作用交联形成。SEM观察显示微球中存在蛋格结构及孔洞。考察了不同因素对微球载药率、包封率和体外释药率的影响。结果表明,海藻酸钠水溶液浓度越高释药率越低,当海藻酸钠与胰蛋白酶质量比为4,海藻酸钠水溶液浓度为4%时呈最大的包封率和载药量;随着海藻酸钠与胰蛋白酶质量比增大,载药率降低,包封率呈先增后降变化趋势。

英文摘要：

The spherical alginate-trypsin microcapsules were prepared by the ionotropic gelation method,which formed the microcapsules by adding sodium alginate-trypsin into aqueous solution containing CaCl2.The infrared analysis shows that the matrix in microspheres is cross-linked by electrostatic attraction existed between Ca2＋and—COO-in alginate.The SEM images indicate that ＂egg-box＂ structure and holes exist in the microparticles.The experiments were carried out to evaluate the properties of the microparticles such as drug loading rate,encapsulation efficiency rate and in vitro release rate.The results indicate that the in vitro release rate decreases with increasing the sodium alginate concentration,the encapsulation efficiency and the drug loading get the highest point when the mass ratio of sodium alginate to trypsin is 4 and the sodium alginate concentration in water is 4%.As the mass radio of sodium alginate to trypsin increases,the drug loading decreases and the encapsulation efficiency increases at first and then decreases.