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苯并螺环β-溴代酮Wagner-Meerwein重排反应研究及其在（±）-Colchicine形式合成中的应用
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 时间：0
  • 分类：O621.262[理学—有机化学;理学—化学]
  • 作者机构：[1]兰州大学化学化工学院功能有机分子化学国家重点实验室,兰州730000
  • 相关基金：国家自然科学基金（Nos.20021001,203900501）和长江学者基金资助项目.
作者： 王爱霞[1], 宋振雷[1], 高栓虎[1], 姜毅君[1], 袁道义[1], 涂永强[1], 李宁子[1]
关键词： AgBF4, 三环体系, (±)-colchicine, 苯并螺环β-溴代酮, Wagner-Meerwein重排反应, AgBF4, tricyclic system, （±）-colchicine, benzospirocyclic fl-bromo ketones, Wagner-Meerwein rearrangement
中文摘要：

报道了在AgBF4促进下苯并螺环β-溴代酮的Wagner-Meerwein重排反应,从而发展了一条简捷新颖的构筑天然产物中广泛存在的n,7,6-三环骨架的方法.作为该反应的应用,合成了（±）-colchicine的7,7,6-三环母核,完成了（±）-colchicine的形式合成.

英文摘要：

Studies on the Wagner-Meerwein rearrangement of benzospirocyclic fl-bromo ketones to n,7,6- tricyclic systems under the promotion of AgBF4 are reported in this paper. Application of this method led to a new approach to 7,7,6-membered core, and thus constituents a formal synthesis of （4-）-colchicine.

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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408