中文摘要：

骨桥蛋白（OPN）是从骨细胞中提取出来的酸性糖蛋白,在细胞的黏附、侵袭、抗凋亡和促血管生成等方面具有重要作用,在胃癌、肝癌、卵巢癌及甲状腺癌中均呈高表达,但在正常人体中一般呈弱表达或不表达。子宫内膜异位症（EMs）在病理上虽为良性疾病,却有着类似于肿瘤的侵袭、种植及远处转移等生物学行为,且其治疗方案局限。因此,本文就OPN可能通过核转录因子κB（NF-κB）通路介导基质金属蛋白酶（MMPs）、尿激酶型纤溶酶原激活物（uPA）的表达来诱导EMs的发生和发展进行综述,并概述其生物学特点及各因子在EMs发病机制中的作用,旨在为EMs的靶向药物治疗提供一种新的思路。

英文摘要：

Osteopontin（OPN）is the acid glycoprotein that extracted from the bone cells,and it plays an important role in cell adhesion,invasion,anti - apoptosis and angiogenesis promotion. It presents high expression in gastric cancer,liver cancer,ovarian cancer and thyroid cancer,but weak or low expression in normal human bodies. Endometriosis（ EMs）is pathologically a benign disease,but it has biological behaviors that similar to tumor,such as invasion,planting and distant metastasis,moreover it has limited treatment schedules. OPN may mediate the expression of matrix metalloproteinases（MMPs） and urokinase - type plasmase activator（uPA）through nuclear transcription factor κB（NF - κB）pathway,and then induce the occurrence and development of EMs. Therefore,the paper reviews the above process and summarizes its biological characteristics and the role of each factor in EMs pathogenesis,aiming to provide a new idea for targeted drug therapy of EMs.