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Identification of common variants within KCNK17 in Chinese Han population
  • ISSN号：1672-0733
  • 期刊名称：华中科技大学学报(医学英德文版)
  • 时间：0
  • 页码：13-17
  • 语言：中文
  • 分类：Q987[生物学—遗传学;生物学—人类学]
  • 作者机构：[1]Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology The Institute of Hypertension and Department of Internal Medicine
  • 相关基金：supported by grants from National Nature Science Foundation Committee of China(No.30600187,No.30770751)
  • 相关项目：扩散性抑制和胶质细胞活化与局灶性脑缺血后迟发性神经元死亡关系的研究
作者： Ding, Hu|Tang, Zhouping|Xu, Shabei|Xu, Yujun|
中文摘要：

KCNK17 is a member of the acid-sensitive subfamily of tandem pore K+ channels,which are open at all membrane potentials and contribute to cellular resting membrane potential.Recent genome-wide study(GWA)has shown that variants within KCNK17 confer genetic susceptibility for increasing ischemic stroke.In an effort to discover additional polymorphism(s),we scrutinized the genetic polymorphisms in the KCNK17.By direct DNA sequencing in 32 individuals,we identified nine sequence variants within the 16kb of whol...

英文摘要：

KCNK17 is a member of the acid-sensitive subfamily of tandem pore K+ channels,which are open at all membrane potentials and contribute to cellular resting membrane potential.Recent genome-wide study(GWA)has shown that variants within KCNK17 confer genetic susceptibility for increasing ischemic stroke.In an effort to discover additional polymorphism(s),we scrutinized the genetic polymorphisms in the KCNK17.By direct DNA sequencing in 32 individuals,we identified nine sequence variants within the 16kb of whol...

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期刊信息
  • 《华中科技大学学报：医学英德文版》
  • 主管单位:
  • 主办单位:华中科技大学
  • 主编：
  • 地址：武汉硚口区航空路13号同济医科大学内
  • 邮编：430030
  • 邮箱：
  • 电话：027-83692514
  • 国际标准刊号：ISSN：1672-0733
  • 国内统一刊号：ISSN：42-1679/R
  • 邮发代号:38-56
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引（扩展库）
  • 被引量:597