中文摘要：

Neurochip 基于光设法解决的 potentiometric 传感器(臀部) ，谁的察觉到元素是易兴奋的房间，有细胞的信号的有教养的神经原网络的罐头监视器 electrophysiological 性质很好分析了。这里，我们与与臀部和基于小浪降噪信号的一个方法混合的房间转变的老鼠 pheochromocytoma (PC12 ) 报导一种 neurochip。房间在臀部上是有教养的几天了形成网络，并且我们然后使用了臀部系统检测细胞外的潜力，信号在时间频率空格根据分解降噪。信号被分解成各种各样的规模，并且系数基于每层的性质被处理。最后，信号基于新系数被重建。结果证明在降噪以后，基线飘移被移开， signal-to-noise 比率被增加。它建议联合到臀部的 PC12 房间的 neurochip 为有小浪的性质转变的房间 electrophysiological 的长期、非侵略的测量稳定、合适，利用它的时间频率本地化分析减少噪音。关键词 Neurochip - 光设法解决的 potentiometric 传感器(臀部)- 小浪变换 - 阀值 - 降噪 CLC 数字 Q27 工程由中国的国家自然科学基础支持了(Nos. 30700167 并且 60725102 ) ，中国的变换器技术的国家重点实验室的工程(没有。SKT0702 ) ，中国的浙江省的自然科学基础(没有。Y2080673 ) ，并且浙江省的教育系的科学研究资金，中国(没有。Y200909323 ）

英文摘要：

Neurochip based on light-addressable potentiometric sensor（LAPS）,whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma（PC12） cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency space.The signal was decomposed into various scales,and coefficients were processed based on the properties of each layer.At last,signal was reconstructed based on the new coefficients.The results show that after de-noising,baseline drift is removed and signal-to-noise ratio is increased.It suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.