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中文摘要：
抑郁症以持续情绪低落和认知功能障碍为主要临床特征，包括焦躁情绪、快感缺失、睡眠障碍、负罪感和反复自杀念头等。抑郁症不仅给患者带来精神上的损失，也给患者造成沉重的经济负担。该文结合抑郁症相关假说：单胺假说、应激假说、神经营养因子和神经元新生假说等，根据不同的发病机制和作用通路，对抑郁症治疗进展进行综述和展望。
英文摘要：
Depression is characteristic with sustained depressive mood and cognitive dysfunction in the clinic, including restless- ness, anhedoina, sleep disorders, guilt and repeated thoughts of suicide and so on. Depression not only damages the mentality of patients, bu also brings a heavy financial burden to patients. Based on the depression-related hypothesis：the monoamine hy-pothesis, stress hypothesis, neurotrophic factors and neurogenesis hypotheses etc. , and from different mechanisms and signal path- was, we reviewed the progress of the treatment of depression.
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