中文摘要：

目的探讨通心络干预对冠状动脉微栓塞后心肌间质重塑及左心室功能的影响。方法雄性sD大鼠60只，随机分为对照组、微栓塞组和通心络组，每组分为术后3天和4周两个观察时间点，每时间点10只。术后3天观察冠状动脉微栓塞后心肌病理学改变；术后4周观察心肌间质胶原纤维面积、小冠状动脉血管密度及左心室功能变化情况。结果术后3天，微栓塞组心肌内点状分布的坏死灶形成，多位于心内膜下，周围炎症细胞浸润明显增多，符合微栓塞病理学改变。与微栓塞组比较，通心络干预4周后心肌间质胶原纤维沉积明显减轻，小冠状动脉密度显著增加；同时左心室腔减小，左心室壁增厚，心功能明显改善。结论大鼠冠状动脉微栓塞后，予通心络干预4周能减轻心肌间质的重塑，并改善左心室功能。

英文摘要：

Aim To investigate the effect of Tongxinluo capsules on cardiac interstitium remodeling and left ventricular function after coronary microembolization. Methods 60 male SD rats were randomly separated into three groups ： control group, coronary microembolization group and tongxinluo group, each group consisted of 20 rats. After 3 days for operation, morphological characteristics were evaluated by HE staining; after 4 weeks for operation, collagen deposition were calculated by Sirius-red staining, intramyocardial arteriole detected by immunnostaining for factor α-actin antibody, left ventricular function measured by echocardiography. Results After 3 days for operation, HE staining showed multi-focal myocardial necrosis with inflammatory cells infiltration and necrosis with more involvement in subendocardial region. After 4 weeks for operation, compared with coronary microembolization group, the area of myocardial collagen were decreased in tongxinluo group, and the density of intramyocardial arteriole increased. Left ventricular end-diastole dimension（ LVEDD）, left ventricular end-systolic dimension （LVESD） were smaller, left ventricular posterior wall thickness （ LVPWT} thicker and left ventricular ejection fraction （LVEF） higher in tongxinluo group than those in coronary microembolization group. Conclusion Intervention with tongxinluo capsules for 4 weeks can reduce cardiac interstitium remodeling and improve left ventricular function after coronary microembolization in rats.