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葛根素与卵磷脂囊泡的相互作用
  • ISSN号：0023-074X
  • 期刊名称：《科学通报》
  • 时间：0
  • 分类：O64[理学—物理化学;理学—化学]
  • 作者机构：[1]扬州大学化学化工学院,扬州225002
  • 相关基金：国家自然科学基金资助项目（批准号：20633010）
作者： 奚菊群[1], 郭荣[1]
关键词： 卵磷脂, 囊泡, 葛根素, 药物包埋
中文摘要：

通过紫外可见光谱、红外光谱、Zeta电势和量子力学从头算等方法研究了生理条件下（pH7．4）葛根素与卵磷脂囊泡的相互作用．结果表明，在卵磷脂囊泡体系中，葛根素能与囊泡发生显著的相互作用，葛根素主要以分子中的B环部分定位于囊泡的疏水微区中，并且卵磷脂体系有利于葛根素分子的酸碱平衡向去质子化的方向移动．葛根素分子上的羟基与磷脂分子的极性头基在膜／水界面上形成的氢键结构增强了卵磷脂双层膜的规整性和稳定性，从而导致磷脂膜的流动性和渗透性的降低．

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期刊信息
  • 《科学通报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院
  • 主编：周光召
  • 地址：北京东黄城根北街16号
  • 邮编：100717
  • 邮箱：csb@scichina.org
  • 电话：010-64036120 64012686
  • 国际标准刊号：ISSN：0023-074X
  • 国内统一刊号：ISSN：11-1784/N
  • 邮发代号:80-213
  • 获奖情况:
  • 首届国家期刊奖,中国期刊方阵“双高”期刊,第三届中国出版政府奖
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  • 美国化学文摘（网络版）,美国数学评论（网络版）,美国工程索引,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:81792