中文摘要：

目的：探讨胰腺癌患者术前血清中CA19-9与CEA表达情况对预后的影响。方法：回顾分析医院2012年1月～2013年12月128例胰腺癌患者临床病理资料，应用Kaplan．Meier法、Log—rank检验及Cox回归分析CA19-9和CEA水平与患者生存时间的关系。血清中CA19-9〉39U／mL，CEA〉4．7ng／mL被视为表达增高。结果：128例患者平均年龄为62岁，中位生存期为12．2月，其中CA19—9和CEA的表达水平增高的比例分别为78．1％，37．5％。CA19-9、CEA升高组患者的预后明显差于正常组（CA19-9，P=0．027；CEA，P=0．036）。Cox多因素回归分析显示淋巴结转移、CA19—9〉39U／mL、CEA〉4．7ng／mL是影响胰腺癌患者预后的独立因素。结论：术前CA19-9、CEA水平与胰腺患者生存时间密切相关，能有效评估患者的预后。

英文摘要：

Objective： To explore the use of preoperative CA19-9 and CEA serum levels as prognostic factors to affect survival in pancreatic cancer. Methods： A retrospective review of the clinical records of 128 patients with pancreatic adenocarcinoma between January, 2012 and December, 2013 was performed. Kaplan-Meier method, log-rank test and Cox regression analysis models were used to investigate the relationship between the levels of CA19-9 and CEA and survival outcome. The cut-off for CA19-9, CEA was 39 U/mL and 4.7 ng/mL. Results： The mean age of 128 patients was 62 years, and the median survival time was 12.2 months. The positive rate of CA19-9 and CEA were respectively 78.1%, 37.5%. Patients with high CA19-9 or CEA levels suffered a poorer prognosis than the individuals with normal levels （CA19-9, P=0.027; CEA, P=0.036）. Cox logistic analysis revealed that lymphatic metastasis, CA19-9 〉39 U/mL and CEA 〉4.7 ng/mL were independent prognostic factors.Conclusion： The serum levels of preoperative CA19-9 and CEA were significant associated with survival time of pancreatic cancer patients, and could evaluate the prognosis of these patients.