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中文摘要：
为了评估低剂量多次辐射对健康机体产生的生物学风险，检测了X射线多次照射对BALB／c小鼠免疫系统的影响。采用X射线全身多次照射，第1天照射0．07Gy，之后每天照射0．08Gy共12d，剂量率0．2Gy／min，累积剂量为0、0．07、0．23、0．39、0．55、0．71、0．87和1．03Gy时取样。照射24h后取血，用流式细胞仪检测外周血中免疫细胞周期和死亡的变化。结果表明，外周血淋巴细胞的周期在0．39和1．03Gy时，被阻滞在G2/M期，在0．07、0．23、0．71和0．87Gy时，被阻滞在G0／G1期；细胞的死亡随着累积剂量的增加而增加，在0．71Gy时达到峰值。经过X射线多次全身照射小鼠后，可引起外周血淋巴细胞周期和死亡比例发生变化，符合线性平方模型，造成其免疫系统一定的损伤。
英文摘要：
For estimating biological risks from low doses continual irradiation, we investigated the effects of exposure to continuously fractionated X-rays on murine immune system. The BALB/c mice were irradiated with 0.07Gy at the first day and 0.08 Gy/d in the following 12 days at a dose rate of 0.2 Gy/min. The peripheral blood lymphocyte cycle and death were determined by flow cytometry at the cumulative doses of 0, 0.07, 0.23, 0.39, 0.55, 0.71, 0.87 and 1.03 Gy respectively. The results showed that the cycle of peripheral blood lymphocyte was arrested in G0/G1 at cumulative doses of 0.07, 0.23, 0.71 and 0.87 Gy, and in G2/M at cumulative doses of 0.39 and 1.03 Gy; the percentage of death of peripheral blood lymphocyte was ascended with dose increasing, and reached the death peak at cumulative doses of 0.71 Gy. The results suggested that low doses continual X-rays total-body irradiated could result in changes of cellular cycle and death, and some damages to immunocytes, which accorded to linear square model.
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