中文摘要：

目的：以大承气汤治疗机械性肠梗阻的药效为介入点,采用混料均匀设计法进行大承气汤配比研究,运用因子分析与偏最小二乘回归法处理分析数据,以期为机械性肠梗阻的临床用药提供理论依据。方法：采用距离盲肠端1 cm处的小肠1/2横断面结扎法,建立大鼠急性肠梗阻模型,通过大鼠排便情况,考察大鼠小肠功能,并测量梗阻处的小肠周长,梗阻处小肠的肠黏膜微循环的血流,以及小肠的梗阻率。结果：与模型组比较,大承气汤多数配比方能显著缩短排便潜伏期、降低梗阻率、增加24 h内的排便数量以及肠黏膜血流量,并且12个配方中配方2的效果最佳。结论：提示临床在使用大承气汤治疗机械性肠梗阻时,在改善大便不畅及肠微循环障碍方面除了君药大黄的应用,也应重视厚朴这味行气药的应用。

英文摘要：

Objective：Taking the efficacy of Dachengqi Decoction on mechanical intestinal obstruction as the intervention point,to study compatibility of Dachengqi Decoction by the mixing uniform design method and use factor analysis and partial least squares regression analysis to do the data processing, with a view to provide a theoretical basis for the mechanical intestinal obstruction. Methods ： Through 1/2 cross - sectional ligation method on the small intestine 1 cm away from caecum, we established rat model of acute intestinal obstruction. By defecation in rats, we investigated the rats＇ small intestine function and measured the circumference of the obstruction at the small intestine, the blood flow in microcirculation in the intestinal mucosa of the small in- testine and the rate of intestinal obstruction. Results ： Compared with the model group, most proportions of Dachengqi Decoction sig- nificantly shortened the defecation latency,reduced the obstruction rate, increased the number of bowel movements and intestinal mucosal blood flow within 24 hours. And among 12 kinds of proportions, there were 2 kinds of proportions with the best results. Conclusion ： When using Dachengqi Decoction in the treatment of mechanical intestinal obstruction and bowel obstruction in improving microcireulation,apart from rhubarb,we should pay attentionto Magnolia bark which is a kind of qiactivating drugs.