中文摘要：

Kaposissarcoma-associatedherpesvirus (KSHV ) isadoublestrandedDNAvirus.Itwasfound toberelatedtoKaposissarcoma (KS ) ， primaryeffusionlymphoma (像素) andmulticentricCastlemans 疾病(MCD ) ， whichcausesevereillnessinAIDSpatients.Asamemberofhumanherpesvirusfamily KSHVdisplaystwodistinctphasesinitslifecycle， thedefaultlatentandlyticreplicationphase.Followingprimaryinfection， theviruscanquicklyestablishlatentinfectioninthehost.However， itisstillnot ...ThemechanismofKSHV mediatedpathogenesisisalsolargelyunknown。Inthisreview， wesummarizetherecentprogressinthemechanismsofKSHVlatencyandpathogenesis， withparticularviewsfromourwork

英文摘要：

Kaposi＇s sarcoma-associated herpesvirus （KSHV） is a double stranded DNA virus. It was found to be related to Kaposi＇s sarcoma （KS）, primary effusion lymphoma （PEL） and multicentric Castleman＇s disease （MCD）, which cause severe illness in AIDS patients. As a member of human herpesvirus family, KSHV displays two distinct phases in its life cycle, the default latent and lytic replication phase. Following primary infection, the virus can quickly establish latent infection in the host. However, it is still not fully understood up to date how KSHV establishes and maintains viral latency in the host cells. KSHV mainly infects endothelial cells in the host, promoting proliferation and angiogenesis. Abundant angiogenesis is the key feature of KS and is the critical factor for KS progression. The mechanism of KSHV mediated pathogenesis is also largely unknown. In this review, we summarize the recent progress in the mecha- nisms of KSHV latency and pathogenesis, with particular views from our work.