中文摘要：

目的 探讨成年人睡眠时间与脑卒中患病的关系.方法 使用“中国慢性病前瞻性研究”（CKB）浙江省桐乡市项目点57 704名30 ～ 79岁常住居民有效基线调查数据,使用多重logistic回归分析通过调整可能的混杂因素研究睡眠时间和脑卒中患病的关系.结果 调查对象中男性和女性的平均年龄分别为（53.15±10.20）岁和（51.72±9.69）岁,14.43％的男性和15.30％的女性报告睡眠时间≤6 h/d,5.39％的男性和5.95％的女性报告睡眠时间≥10 h/d.男性脑卒中患病率为0.92％,女性为0.44％,均随睡眠时间呈“U”形的分布.在调整年龄、社会经济状况、行为习惯和健康状态的因素后,与7 h/d睡眠时间相比,睡眠时间≥10 h/d与男女性脑卒中患病均存在关联,OR值分别为2.11 （95％CI： 1.32～ 3.37）和2.13（95％CI： 1.24～3.65）,睡眠时间不足与脑卒中之间未见统计学关联.此外,女性睡眠时经常打鼾也与脑卒中的患病相关（OR=1.63,95％CI： 1.11～2.40）.结论 睡眠时间过长与脑卒中患病存在关联,女性睡眠时经常打鼾能够增加脑卒中的患病风险.

英文摘要：

Objective To explore the association between sleep duration and stroke in adults.Methods Baseline data of 57 704 subjects who were aged 30-79 years and enrolled into China Kadoorie Biobank （CKB） study from Tongxiang county, Zhejiang province were analyzed.Multiple logistic regression analysis was conducted to investigate the putative association between sleep duration and stroke after adjusting for potential confounders.Results The mean age of the subjects was （53.15 4 10.20） years in males and （51.72 ± 9.69） years in females, respectively.There were 14.43% of males and 15.30% of females reporting sleep durations ≤6 hours per day and 5.39% of males and 5.95% of females reporting long duration of sleep （≥ 10 hours per day）.The prevalence of stroke was 0.92% in males compared with 0.44% in females.The prevalence of stroke showed a U-shaped distribution with sleep duration.Compared with 7 hours sleep duration per day, long sleep duration （≥10 hours per day） was associated with stroke.The odds ratios （OR） were 2.11 （95%CI：1.32-3.37） for males and 2.13 （95%CI： 1.24-3.65） for females after adjusting for age, socioeconomic status, health behaviors and health status.No statistical significant association was found between short sleep duration and stroke.Meanwhile, frequent sleep snoring was found to be associated with stroke in females （OR =1.63,95%CI：1.11-2.40）.Conclusion Longer sleep duration was found to be associated with higher risk of stroke in both males and females.Frequent sleep snoring would increase the risk of stroke in females.