中文摘要：

In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert,a systematically phytochemical investigation was carried out.The constituents were isolated by silica gel,Sephadex LH-20,MCI gel,ODS column chromatography,and semi-preparative HPLC.Their structures were determined on the basis of MS and NMR spectroscopic analyses,by chemical methods,and/or comparison with literature data.The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects on the lipopolysaccharide（LPS）-induced nitric oxide（NO）production in BV-2 mouse microglial cells.Nine iridoids were isolated and identified as cistadesertoside A（1）,cistanin（2）,cistachlorin（3）,6-deoxycatalpol（4）,gluroside（5）,kankanoside A（6）,ajugol（7）,bartsioside（8）,and 8-epi-loganic acid（9）.Compound 9 exhibited potent inhibition on the NO production with an IC50 value being 5.2 μmol·L-1,comparable to the positive control quercetin(4.3 μmol·L-1).Compound 1 was a new iridoid,and compounds 5,6,and 8 were isolated from this species for the first time.

英文摘要：

In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert, a systematically phytochemical investigation was carried out. The constituents were isolated by silica gel, Sephadex LH-20, MCI gel, ODS column chromatography, and semi-preparative HPLC. Their structures were determined on the basis of MS and NMR spectroscopic analyses, by chemical methods, and/or comparison with literature data. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects on the lipopolysaccharide （LPS）-induced nitric oxide （NO） production in BV-2 mouse microglial cells. Nine iridoids were isolated and identified as cistadesertoside A （1）, cistanin （2）, cistachlorin （3）, 6-deoxycatalpol （4）, gluroside （5）, kankanoside A （6）, ajugol （7）, bartsioside （8）, and 8-epi-loganic acid （9）. Compound 9 exhibited potent inhibition on the NO production with an IC50 value being 5.2 μmol-L 1, comparable to the positive control quercetin （4.3 μmol.L-1）. Compound 1 was a new iridoid, and compounds 5, 6, and 8 were isolated from this species for the first time.