中文摘要：

近年来，肿瘤能量代谢的研究逐渐成为热点。已有研究表明，多种因子参与对肿瘤能量代谢的调控，其中尤以葡萄糖转运蛋白1（ GLUT1）的作用最为关键。研究发现， GLUT1不仅能够调控肿瘤细胞对葡萄糖的摄取，维持葡萄糖的基础代谢；同时GLUT1还在多种肿瘤中异常表达，以满足肿瘤细胞快速生长对能量的需求，对维持肿瘤细胞的生长、分化、转移及预后也发挥关键的调控作用。与此同时，随着GLUT1三维晶体结构的解析，设计出GLUT1的小分子抑制剂，从而实现“饿死”肿瘤细胞的目的已经成为了可能。这使得GLUT1作为治疗靶点，备受人们关注。该文主要对GLUT1与肿瘤能量代谢的关系研究进展进行综述，探讨GLUT1介导调控肿瘤能量代谢的分子机制及其与临床治疗肿瘤的策略，为临床的后续研究和治疗提供重要参考。

英文摘要：

The study on tumor metabolism has been gradually be-come a hot spot in recent years .A lot of proteins involved in the regulation of tumor metabolism especially the glucose transporter protein 1（GLUT1）.As a key regulatory factor mediating energy metabolism within tumor cells , GLUT1 can regulate the glucose intake and maintain the basic level of metabolism in tumor cells . More importantly, the abnormal expression of GLUT1 was asso-ciated with many kinds of tumors , of which GLUT1 was used to meet the energy requirement for the fast growth of tumor .Thus GLUT1 also played a crucial role in growth , differentiation and metastasis of tumor cells and prognosis of tumors .Meanwhile ,＆nbsp;as three-dimensional crystal structure of GLUT 1 was determined , it is possible to design the small molecular inhibitors of GLUT 1, which can realize “starve to death” tumor cells.GLUT1 can be a particularly attractive target for tumor treatment and interfer-ence.The relationship between abnormal expression of GLUT 1 protein and tumor metabolism was reviewed . Moreover , the mechanism of tumor metabolism regulated by GLUT 1 protein ex-pression and treatment of cancers were discussed , which may provide references for future research and clinical treatment .