中文摘要：

目的观察川芎、白芍及川芎-白芍药对水煎液对离体小鼠子宫平滑肌的影响。方法利用离体小鼠子宫收缩实验,观察药物对缩宫素引起子宫痉挛收缩的收缩频率、收缩幅度的抑制作用,计算抑制率。结果各水煎液对小鼠离体子宫平滑肌收缩频率有抑制作用,白芍中剂量组、川芎-白芍中剂量组抑制率有统计学差异（P〈0.05）,白芍大剂量组、川芎-白芍小剂量组有显著性差异（P〈0.01）,其余各组无统计学差异。对于收缩幅度的抑制,白芍大剂量组与对照组相比较有统计学差异（P〈0.05）,其余各组差异不显著。结论川芎、白芍及川芎-白芍药对水煎液在体外对子宫平滑肌收缩有抑制作用。

英文摘要：

ObjectiveTo study the effects of Rhizoma Chuanxiong,Radix Paeoniae Alba and the drug-pairs on mouse uterine smooth muscle contraction in vitro.MethodsMouse uterine smooth muscle contraction models was used to evaluate the effect on the rate of contraction and amplitude induced by oxytocin and the inhibition ratio was counted.ResultsThe water extracts of Rhizoma Chuanxiong and Radix Paeoniae Alba and the drug-pairs could inhibit the rate of contraction,and the middle dose groups of Radix Paeoniae Alba and the drug-pairs,the large dose group of Radix Paeoniae Alba and the low dose group of drug-pairs had significant difference as compared to control group（P〈0.01）.For the amplitude of contraction,the large dose group of Radix Paeoniae Alba had statistic difference（P〈0.05）.ConclusionThe water extracts of Rhizoma Chuanxiong and Radix Paeoniae Alba and the drug-pairs have certain pharmacological effects on mouse uterine smooth muscle contractions in vitro.