中文摘要：

目的研究镁离子（Mg^2＋）对神经细胞兴奋性氨基酸N-甲基-D-天冬氨酸（NMDA）损伤的保护作用。方法采用原代培养的大鼠皮层神经细胞模型，给予NMDA损伤，加入不同浓度的Mg^2＋，测定神经细胞损伤噻唑蓝（MTT）变化。结果Mg^2＋对兴奋性氨基酸损伤保护作用在1．0～3．0mmol／L范围内存在，2．0mmol／L效果最可靠。结论在重型颅脑损伤的临床治疗中应尽早使用镁剂，剂量根据脑脊液浓度尽快调整到2．0mmol／L保护作用最好。

英文摘要：

Objective To investigate the neuroproteetive effect of Mg^2＋ for neurons damaged by NMDA. Methods By using primary cultured rat cortical neurons, the change in MTT of neurons damaged by NMDA and protective effect of Mg^2＋ were observed. Results The neuroprotective effect of Mg^2 ＋ related to the concentration of Mg^2＋ between 1.0 - 3.0 mmol/L and effective time. 2.0mmol/L is the best concentration for neuroprotective effect. Conclusion Mg^2＋ should be clinically applied as early as possible, and the dosage should be adjusted to 2.0 mmol/L based on its concentration in CSF.