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中文摘要：
设计了一种特定的化学模型系统，将带有不同官能团（烷基、羧基、羟基、氨基）的硫醇分子自组装在金片表面，研究不同官能团分子对蛋白吸附的影响。实验结果表明，对于两种不同蛋白质牛血清蛋白（BSA）和碱性成纤维细胞生长因子（bFGF），带有疏水性官能团的烷基硫醇自组装膜对蛋白吸附量大于其他3种硫醇自组装膜，即亲疏水性是决定材料表面吸附蛋白的主要因素。另外，材料表面电荷性质也影响蛋白吸附，当表面官能团为带正电基团如氨基，则它对牛血清这类带负电的蛋白的吸附就大于带有羧基、羟基等这类带负电基团的分子，而后者对于正电蛋白的吸附更为明显。
英文摘要：
Biomaterial surface properties influence protein adsorption and elicit diverse cellular responses in biomedical and bioteehnological applications. However, the molecular mechanisms directing cellular activities remain poorly understood. Using a model system with well-defined （-CH3, -OH, -COOH, -NH2 ）, the effects of surface chemistry on protein adhesion were investigated.
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